Sequence-specific transcription factors (TFs) regulate gene expression by binding to cis-
regulatory elements in promoter and enhancer DNA. While studies of TF–DNA binding have …

Enhancers are important genomic regulatory elements directing cell type-specific
transcription. They assume a key role during development and disease, and their …

The mod el organism E ncylopedia of R egulatory Elements (modERN) project was
designed to generate genome-wide binding profiles for the majority of transcription... To …

The developmental role of histone H3K9 methylation (H3K9me), which typifies
heterochromatin, remains unclear. In Caenorhabditis elegans, loss of H3K9me leads to a …

The N-terminal tails of eukaryotic histones are frequently posttranslationally modified. The
role of these modifications in transcriptional regulation is well-documented. However, the …

How transcription factor dimerization impacts DNA-binding specificity is poorly understood.
Guided by protein dimerization properties, we examined DNA binding specificities of 270 …

Chromatin accessibility, a crucial component of genome regulation, has primarily been
studied in homogeneous and simple systems, such as isolated cell populations or early …

Transcription factor (TF) binding specificities (motifs) are essential for the analysis of gene
regulation. Accurate prediction of TF motifs is critical, because it is infeasible to assay all TFs …

Ageing is a complex process with common and distinct features across tissues. Unveiling
the underlying processes driving ageing in individual tissues is indispensable to decipher …

The execution of developmental programs of gene expression requires an accurate
partitioning of the genome into subnuclear compartments, with active euchromatin enriched …