Transcriptional regulation is at the heart of biological functions such as adaptation to a
changing environment or to new carbon sources. One of the mechanisms which has been …

The accumulation of experimental data over recent years has fueled theoretical work on how
transcription factors (TFs) search for and recognise their DNA target sites, how they interact …

The lac repressor protein (LacI) together with its target regulatory sequence are a common
model for studying DNA loo** and its implications on transcriptional control in bacteria …

DNA is subject to large deformations in a wide range of biological processes. Two key
examples illustrate how such deformations influence the readout of the genetic information …

DNA loo** mediated by the Lac repressor is an archetypal test case for modeling protein
and DNA flexibility. Understanding loo** is fundamental to quantitative descriptions of …

The E. coli Lac repressor is the classic textbook example of a protein that attaches to widely
spaced sites along a genome and forces the intervening DNA into a loop. The short loops …

The genetic material in living cells is organized into complex structures in which DNA is
subjected to substantial contortions. Here we investigate the difference in structure …

Genomic DNA is vastly longer than the space allotted to it in a cell. The molecule must fold
with a level of organization that satisfies the imposed spatial constraints as well as allow for …

Tethered particle motion (TPM) experiments can be used to detect time-resolved loop
formation in a single DNA molecule by measuring changes in the length of a DNA tether …

Many gene regulatory motifs in both prokaryotes and eukaryotes involve physical
manipulations of the genetic material, often on length scales short enough that the …