Apoptosis or programmed cell death is natural way of removing aged cells from the body.
Most of the anti-cancer therapies trigger apoptosis induction and related cell death networks …

Telomeres are protective caps at the ends of human chromosomes. Telomeres shorten with
each successive cell division in normal human cells whereas, in tumors, they are …

Hsp90 molecular chaperones are required for the stability and activity of a diverse range of
client proteins that have critical roles in signal transduction, cellular trafficking, chromatin …

The 90-kDa heat-shock protein (Hsp90) is a molecular chaperone responsible for the
stability and function of a wide variety of client proteins that are critical for cell growth and …

Angiogenesis is an important mediator of tumor progression. As tumors expand, diffusion
distances from the existing vascular supply increases, resulting in hypoxia in the cancer …

Pregnancy in humans is a multi-step complex physiological process comprising three
discrete events, decidualization, implantation and placentation. Its overall success depends …

Molecular chaperones are well known as facilitators of protein folding and assembly.
However, in recent years multiple chaperone-assisted degradation pathways have also …

Protein homeostasis (proteostasis) is inextricably tied to cellular health and organismal
lifespan. Aging, exposure to physiological and environmental stress, and expression of …

Ovarian cancer is a serious cause of death in gynecological oncology. Delayed diagnosis
and poor survival rates associated with late stages of the disease are major obstacles …

Bladder cancer (BC) is a complex and highly heterogeneous stem cell disease associated
with high morbidity and mortality rates if it is not treated properly. Early diagnosis with …