Chemokines are a family of small, highly conserved cytokines that mediate various
biological processes, including chemotaxis, hematopoiesis, and angiogenesis, and that …

Despite marked improvements in the survival of patients with severe lupus nephritis over the
past 50 years, the rate of complete clinical remission after immune suppression therapy is< …

Rheumatoid arthritis (RA) is one of the most prevalent autoimmune diseases and a
prototypic inflammatory disease, affecting the small joints of the hands and feet. Chemokines …

Ischemia-reperfusion injury (IRI) is the main cause of morbidity and mortality due to graft
rejection after liver transplantation. During IRI, an intense inflammatory process occurs in the …

Multiple sclerosis (MS) is a chronic inflammatory disease that is characterized by leukocyte
infiltration and subsequent axonal damage, demyelinating inflammation, and formation of …

Innate immune cells, particularly macrophages and epithelial cells, play a key role in
multiple layers of immune responses. Alarmins and pro-inflammatory cytokines from the IL …

Leukocyte migration through interstitial tissues is essential for mounting a successful
immune response. Interstitial motility is governed by a vast array of cell-intrinsic and cell …

Biased signaling or functional selectivity occurs when a 7TM-receptor preferentially activates
one of several available pathways. It can be divided into three distinct forms: ligand bias …

Aim To evaluate the ability of ladarixin (LDX, 400 mg twice‐daily for three cycles of 14 days
on/14 days off), an inhibitor of the CXCR1/2 chemokine receptors, to maintain C‐peptide …

Abstract IL-17-producing helper T (Th17) cells are critical for host defense against
extracellular pathogens but also drive numerous autoimmune diseases. Th17 cells that differ …