Individuals who maintain cognitive function despite high levels of Alzheimer's disease (AD)-
associated pathology are said to be 'resilient'to AD. Identifying mechanisms underlying …

Restless legs syndrome (RLS) is a common sensorimotor disorder for which two main
pathological elements are fairly well accepted: Brain iron deficiency (BID) and an altered …

We have developed workflows to align 3D magnetic resonance histology (MRH) of the
mouse brain with light sheet microscopy (LSM) and 3D delineations of the same specimen …

Preclinical models of neurodevelopmental disorders typically use single inbred mouse
strains, which fail to capture the genetic diversity and symptom heterogeneity that is common …

Microglia shift toward an inflammatory phenotype during aging that is thought to exacerbate
age-related neurodegeneration. The molecular and cellular signals that resolve …

Quantitative traits are often complex because of the contribution of many loci, with further
complexity added by environmental factors. In medical research, systems genetics is a …

Metabolic diseases are caused by a complex interplay between genetics and the
environment, yet many basic studies guiding our understanding of metabolism are confined …

Although germline mutation rates and spectra can vary within and between species,
common genetic modifiers of the mutation rate have not been identified in nature. Here we …

Chronic stress is a major risk factor for psychiatric disorders, including depression. Although
depression is a highly heterogeneous syndrome, it remains unclear how chronic stress …

How lifespan and body weight vary as a function of diet and genetic differences is not well
understood. Here we quantify the impact of differences in diet on lifespan in a genetically …