Glioblastoma (GBM) is a devastating type of brain tumor, and current therapeutic treatments,
including surgery, chemotherapy, and radiation, are palliative at best. The design of effective …

Although pancreatic cancer (PC) was considered in the past an orphan cancer type due to
its low incidence, it may become in the future one of the leading causes of cancer death …

Many cancers have long been thought to primarily metabolize glucose for energy production—
a phenomenon known as the Warburg Effect, after the classic studies of Otto Warburg in the …

CNS-resident macrophages—including parenchymal microglia and border-associated
macrophages (BAMs)—contribute to neuronal development and health, vascularization, and …

Tumour‐associated microglia/macrophages (TAM) are the most numerous non‐neoplastic
populations in the tumour microenvironment in glioblastoma multiforme (GBM), the most …

Glioblastoma multiforme (GBM) is the most hostile type of brain cancer. Its aggressiveness is
due to increased invasion, migration, proliferation, angiogenesis, and a decreased …

Autophagy and the (PI3K-Akt/mTOR) signaling pathway play significant roles in
glioblastoma multiforme (GBM) cell death and survival. Curcumin (Cur) has been reported to …

Immunophilins are a family of proteins whose signature domain is the peptidylprolyl-
isomerase domain. High molecular weight immunophilins are characterized by the …

Old age is the greatest risk factor for most neurodegenerative diseases. During recent
decades there have been major advances in understanding the biology of aging, and the …

Intervertebral disc degeneration (IDD), an important cause of chronic low back pain (LBP), is
considered the pathological basis for various spinal degenerative diseases. A series of …