Develo** in silico models that accurately reflect a whole, functional cell is an ongoing
challenge in biology. Current efforts bring together mathematical models, probabilistic …

High-resolution and rapid imaging of host cell ultrastructure can generate insights toward
viral disease mechanism, for example for a severe acute respiratory syndrome coronavirus …

The intricate mesh of neural connections in the central nervous system (CNS) necessitates
high-resolution observations to gain insights into cellular composition and molecular …

Inter-organelle interactions are a vital part of normal cellular function; however, these have
proven difficult to quantify due to the range of scales encountered in cell biology and the …

Positively charged repeat peptides are emerging as key players in neurodegenerative
diseases. These peptides can perturb diverse cellular pathways but a unifying framework for …

The protocol describes step-by-step sample preparation, data acquisition, and segmentation
of cellular organelles with soft X-ray tomography. It is designed for microscopes built to …

Cells' structure is key to understanding cellular function, diagnostics, and therapy
development. Soft X-ray tomography (SXT) is a unique tool to image cellular structure …

Mitochondria are dynamic organelles that change morphology to adapt to cellular energetic
demands under both physiological and stress conditions. Cardiomyopathies and neuronal …

Soft X‐ray tomography offers rapid imaging of whole, single cells with a few tens of
nanometers spatial resolution without fixation or labeling. Herein, this technique is limited to …

Much of our understanding of the spatial organization of and interactions between cellular
organelles and macromolecular complexes has been the result of imaging studies utilizing …