Vancomycin use is often associated with nephrotoxicity. It remains uncertain, however, to
what extent vancomycin is directly responsible, as numerous potential risk factors for acute …

Methods Clinical practice guidelines for TDM of VCM were reviewed by a practice guideline
committee that consisted of 18 experts in TDM convened from the JSC and the JSTDM. The …

Continuous renal replacement therapy (CRRT) is now commonly used as a means of
support for critically ill patients with renal failure. No recent comprehensive guidelines exist …

ABSTRACT A careful management of antimicrobials is essential in the critically ill with acute
kidney injury, especially if renal replacement therapy is required. Acute kidney injury may …

Objectives: To outline the concepts involved in optimizing antibacterial dosing in critically ill
patients with acute renal failure undergoing continuous renal replacement therapy (CRRT) …

Objectives: In critically ill patients receiving continuous renal replacement therapy, we aimed
to assess the variability of antibiotic trough concentrations, the influence of effluent flow rates …

Continuous renal replacement therapy (CRRT), particularly continuous venovenous
haemofiltration (CVVH) and continuous venovenous haemodiafiltration (CVVHDF), are …

Infectious diseases and impaired renal function often occur in critically ill patients, and
delaying the start of appropriate empiric antimicrobial therapy or starting inappropriate …

Introduction Continuous renal replacement therapy (CRRT) may alter antibiotic
pharmacokinetics and increase the risk of incorrect dosing. In a nested cohort within a large …

Individualization of vancomycin dosing based on therapeutic drug monitoring (TDM) data is
known to improve patient outcomes compared with fixed or empirical dosing strategies …