High serum lactate dehydrogenase (LDH) levels are typically associated with a poor
prognosis in many cancer types. Even the most effective drugs, which have radically …

Primary liver cancer (PLC) is the fourth most frequent cause of cancer-related death. The
high mortality rates arise from late diagnosis and the limited accuracy of diagnostic and …

Cancer stem cells drive tumor initiation, progression, and recurrence, which compromise the
effectiveness of anti-tumor drugs. Here, we report that demethylzeylasteral (DML), a …

Hepatocellular carcinoma (HCC) is the typical inflammation-induced neoplasia. It often
prospers where a chronic liver disease persists, thus leading a strong rationale for immune …

Background. In cancer cells, metabolism is shifted to aerobic glycolysis with lactate
production coupled with a higher uptake of glucose as the main energy source. Lactate …

A hallmark of most cancer cells is an altered metabolism involving a shift to aerobic
glycolysis with lactate production coupled with a higher uptake of glucose as the main …

Hepatocellular carcinoma (HCC) accounts for over 80% of liver cancer cases and is highly
malignant, recurrent, drug‐resistant, and often diagnosed in the advanced stage. It is clear …

Background Tumor proliferation is frequently accompanied by aberrant enzyme production.
We aim to investigate the potential predictive value of both plasma alkaline phosphatase …

Liver function tests (LFTs) have been reported as independent predictors of non-liver
disease-related morbidity and mortality in general population and cancer patients. In this …

Hepatocellular carcinoma is today the sixth leading cause of cancer-related death
worldwide, despite the decreased incidence of chronic hepatitis infections. This is due to the …