[HTML][HTML] Oral delivery of proteins and peptides: Challenges, status quo and future perspectives

Q Zhu, Z Chen, PK Paul, Y Lu, W Wu, J Qi - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Proteins and peptides (PPs) have gradually become more attractive therapeutic molecules
than small molecular drugs due to their high selectivity and efficacy, but fewer side effects …

[HTML][HTML] Manufacturing challenges and rational formulation development for AAV viral vectors

A Srivastava, KMG Mallela, N Deorkar… - Journal of pharmaceutical …, 2021 - Elsevier
Adeno-associated virus (AAV) has emerged as a leading platform for gene delivery for
treating various diseases due to its excellent safety profile and efficient transduction to …

Strategies for overcoming protein and peptide instability in biodegradable drug delivery systems

M Shi, KJ McHugh - Advanced drug delivery reviews, 2023 - Elsevier
The global pharmaceutical market has recently shifted its focus from small molecule drugs to
peptide, protein, and nucleic acid drugs, which now comprise a majority of the top-selling …

[HTML][HTML] How sugars protect proteins in the solid state and during drying (review): Mechanisms of stabilization in relation to stress conditions

MA Mensink, HW Frijlink… - European Journal of …, 2017 - Elsevier
This review aims to provide an overview of current knowledge on stabilization of proteins by
sugars in the solid state in relation to stress conditions commonly encountered during drying …

Nanogels: An overview of properties, biomedical applications and obstacles to clinical translation

KS Soni, SS Desale, TK Bronich - Journal of Controlled Release, 2016 - Elsevier
Nanogels have emerged as a versatile hydrophilic platform for encapsulation of guest
molecules with a capability to respond to external stimuli that can be used for a multitude of …

Factors affecting the physical stability (aggregation) of peptide therapeutics

KL Zapadka, FJ Becher… - Interface …, 2017 - royalsocietypublishing.org
The number of biological therapeutic agents in the clinic and development pipeline has
increased dramatically over the last decade and the number will undoubtedly continue to …

[HTML][HTML] Vaccine instability in the cold chain: mechanisms, analysis and formulation strategies

OS Kumru, SB Joshi, DE Smith, CR Middaugh, T Prusik… - Biologicals, 2014 - Elsevier
Instability of vaccines often emerges as a key challenge during clinical development (lab to
clinic) as well as commercial distribution (factory to patient). To yield stable, efficacious …

Biosynthesized gold nanoparticles maintained nitrogen metabolism, nitric oxide synthesis, ions balance, and stabilizes the defense systems to improve salt stress …

I Wahid, P Rani, S Kumari, R Ahmad, SJ Hussain… - Chemosphere, 2022 - Elsevier
Green synthesis of nanoparticles (NPs) is competent in inducing physiological responses in
plants for combating the abiotic stresses. Considering this, salt stress is one of the most …

The role of Raman spectroscopy in biopharmaceuticals from development to manufacturing

KA Esmonde-White, M Cuellar, IR Lewis - Analytical and Bioanalytical …, 2022 - Springer
Biopharmaceuticals have revolutionized the field of medicine in the types of active
ingredient molecules and treatable indications. Adoption of Quality by Design and Process …

[HTML][HTML] Raman spectroscopy in pharmaceutical product design

A Paudel, D Raijada, J Rantanen - Advanced drug delivery reviews, 2015 - Elsevier
Almost 100 years after the discovery of the Raman scattering phenomenon, related
analytical techniques have emerged as important tools in biomedical sciences. Raman …