Neoadjuvant therapy for pancreatic cancer

C Springfeld, CR Ferrone, MHG Katz… - Nature Reviews …, 2023 - nature.com
Patients with localized pancreatic ductal adenocarcinoma (PDAC) are best treated with
surgical resection of the primary tumour and systemic chemotherapy, which provides …

Pancreatic cancer

JD Mizrahi, R Surana, JW Valle, RT Shroff - The Lancet, 2020 - thelancet.com
Pancreatic cancer is a highly fatal disease with a 5-year survival rate of approximately 10%
in the USA, and it is becoming an increasingly common cause of cancer mortality. Risk …

Multidisciplinary standards of care and recent progress in pancreatic ductal adenocarcinoma

AJ Grossberg, LC Chu, CR Deig… - CA: a cancer journal …, 2020 - Wiley Online Library
Despite tremendous gains in the molecular understanding of exocrine pancreatic cancer,
the prognosis for this disease remains very poor, largely because of delayed disease …

Therapeutic developments in pancreatic cancer: current and future perspectives

JP Neoptolemos, J Kleeff, P Michl, E Costello… - Nature reviews …, 2018 - nature.com
The overall 5-year survival for pancreatic cancer has changed little over the past few
decades, and pancreatic cancer is predicted to be the second leading cause of cancer …

Total neoadjuvant therapy with FOLFIRINOX in combination with losartan followed by chemoradiotherapy for locally advanced pancreatic cancer: a phase 2 clinical …

JE Murphy, JY Wo, DP Ryan, JW Clark, W Jiang… - JAMA …, 2019 - jamanetwork.com
Importance Patients with locally advanced pancreatic cancer have historically poor
outcomes. Evaluation of a total neoadjuvant approach is warranted. Objective To evaluate …

Pancreatic adenocarcinoma, version 2.2017, NCCN clinical practice guidelines in oncology

MA Tempero, MP Malafa, M Al-Hawary… - Journal of the National …, 2017 - jnccn.org
Ductal adenocarcinoma and its variants account for most pancreatic malignancies. High-
quality multiphase imaging can help to preoperatively distinguish between patients eligible …

Total neoadjuvant therapy with FOLFIRINOX followed by individualized chemoradiotherapy for borderline resectable pancreatic adenocarcinoma: a phase 2 clinical …

JE Murphy, JY Wo, DP Ryan, W Jiang, BY Yeap… - JAMA …, 2018 - jamanetwork.com
Importance Patients with borderline-resectable pancreatic ductal adenocarcinoma have
historically poor outcomes with surgery followed by adjuvant chemotherapy. Evaluation of a …

Pancreatic ductal adenocarcinoma: current and evolving therapies

A Adamska, A Domenichini, M Falasca - International journal of molecular …, 2017 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC), which constitutes 90% of pancreatic cancers, is
the fourth leading cause of cancer-related deaths in the world. Due to the broad …

Magnetic resonance linear accelerator technology and adaptive radiation therapy: An overview for clinicians

WA Hall, E Paulson, XA Li, B Erickson… - CA: a cancer journal …, 2022 - Wiley Online Library
Radiation therapy (RT) continues to play an important role in the treatment of cancer.
Adaptive RT (ART) is a novel method through which RT treatments are evolving. With the …

Using adaptive magnetic resonance image‐guided radiation therapy for treatment of inoperable pancreatic cancer

S Rudra, N Jiang, SA Rosenberg, JR Olsen… - Cancer …, 2019 - Wiley Online Library
Background Adaptive magnetic resonance imaging‐guided radiation therapy (MRgRT) can
escalate dose to tumors while minimizing dose to normal tissue. We evaluated outcomes of …