[HTML][HTML] Drosophila adult muscle development and regeneration
RD Gunage, N Dhanyasi, H Reichert… - Seminars in cell & …, 2017 - Elsevier
Myogenesis is a highly orchestrated, complex developmental process by which cell lineages
that are mesodermal in origin generate differentiated multinucleate muscle cells as a final …
that are mesodermal in origin generate differentiated multinucleate muscle cells as a final …
TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals
The metalloprotease ADAM10/Kuzbanian catalyzes the ligand-dependent ectodomain
shedding of Notch receptors and activates Notch. Here, we show that the human …
shedding of Notch receptors and activates Notch. Here, we show that the human …
The three-dimensional genome drives the evolution of asymmetric gene duplicates via enhancer capture-divergence
Previous evolutionary models of duplicate gene evolution have overlooked the pivotal role
of genome architecture. Here, we show that proximity-based regulatory recruitment by …
of genome architecture. Here, we show that proximity-based regulatory recruitment by …
Epithelial apoptotic pattern emerges from global and local regulation by cell apical area
Geometry is a fundamental attribute of biological systems, and it underlies cell and tissue
dynamics. Cell geometry controls cell-cycle progression and mitosis and thus modulates …
dynamics. Cell geometry controls cell-cycle progression and mitosis and thus modulates …
Activation of the Notch signaling pathway in vivo elicits changes in CSL nuclear dynamics
A key feature of Notch signaling is that it directs immediate changes in transcription via the
DNA-binding factor CSL, switching it from repression to activation. How Notch generates …
DNA-binding factor CSL, switching it from repression to activation. How Notch generates …
Notch and EGFR regulate apoptosis in progenitor cells to ensure gut homeostasis in Drosophila
T Reiff, ZA Antonello, E Ballesta‐Illán, L Mira… - The EMBO …, 2019 - embopress.org
The regenerative activity of adult stem cells carries a risk of cancer, particularly in highly
renewable tissues. Members of the family of inhibitor of apoptosis proteins (IAP s) inhibit …
renewable tissues. Members of the family of inhibitor of apoptosis proteins (IAP s) inhibit …
Notch cooperates with Lozenge/Runx to lock haemocytes into a differentiation programme
A Terriente-Felix, J Li, S Collins, A Mulligan… - …, 2013 - journals.biologists.com
The diverse functions of Notch signalling imply that it must elicit context-specific programmes
of gene expression. With the aim of investigating how Notch drives cells to differentiate, we …
of gene expression. With the aim of investigating how Notch drives cells to differentiate, we …
A mutation in EGF repeat-8 of Notch discriminates between Serrate/Jagged and Delta family ligands
S Yamamoto, WL Charng, NA Rana, S Kakuda… - Science, 2012 - science.org
Notch signaling affects many developmental and cellular processes and has been
implicated in congenital disorders, stroke, and numerous cancers. The Notch receptor binds …
implicated in congenital disorders, stroke, and numerous cancers. The Notch receptor binds …
Quantitative microscopy of the Drosophila ovary shows multiple niche signals specify progenitor cell fate
W Dai, A Peterson, T Kenney, H Burrous… - Nature …, 2017 - nature.com
Adult stem cells commonly give rise to transit-amplifying progenitors, whose progeny
differentiate into distinct cell types. It is unclear if stem cell niche signals coordinate fate …
differentiate into distinct cell types. It is unclear if stem cell niche signals coordinate fate …
Dissecting the mechanisms of Notch induced hyperplasia
The outcome of the Notch pathway on proliferation depends on cellular context, being
growth promotion in some, including several cancers, and growth inhibition in others. Such …
growth promotion in some, including several cancers, and growth inhibition in others. Such …