Interleukin-22: immunobiology and pathology
Interleukin-22 (IL-22) is a recently described IL-10 family cytokine that is produced by T
helper (Th) 17 cells, γδ T cells, NKT cells, and newly described innate lymphoid cells (ILCs) …
helper (Th) 17 cells, γδ T cells, NKT cells, and newly described innate lymphoid cells (ILCs) …
Interleukin 17 is a chief orchestrator of immunity
M Veldhoen - Nature immunology, 2017 - nature.com
Increased understanding of the biology of interleukin 17 (IL-17) has revealed that this
cytokine is a central player in immunity at the sites most exposed to microorganisms …
cytokine is a central player in immunity at the sites most exposed to microorganisms …
Therapeutic opportunities of the IL-22–IL-22R1 system
R Sabat, W Ouyang, K Wolk - Nature reviews Drug discovery, 2014 - nature.com
Abstract Interleukin-22 (IL-22) is a key effector molecule that is produced by activated T cells,
including T helper 22 (TH22) cells, TH17 cells and TH1 cells, as well as subsets of innate …
including T helper 22 (TH22) cells, TH17 cells and TH1 cells, as well as subsets of innate …
The IL-23–IL-17 axis in inflammatory arthritis
E Lubberts - Nature Reviews Rheumatology, 2015 - nature.com
The discovery that the IL-23–IL-17 immune pathway is involved in many models of
autoimmune disease has changed the concept of the role of T-helper cell subsets in the …
autoimmune disease has changed the concept of the role of T-helper cell subsets in the …
[HTML][HTML] Th17 cells: biology, pathogenesis of autoimmune and inflammatory diseases, and therapeutic strategies
Th17 cells that secrete the cytokines IL-17A and IL-17F and express lineage-specific
transcription factor RORC (RORγt in mice) represent a distinct lineage of CD4+ T cells …
transcription factor RORC (RORγt in mice) represent a distinct lineage of CD4+ T cells …
The IL-20 subfamily of cytokines—from host defence to tissue homeostasis
Abstract The interleukin-20 (IL-20) subfamily of cytokines comprises IL-19, IL-20, IL-22, IL-24
and IL-26. These cytokines are all members of the larger IL-10 family, but have been …
and IL-26. These cytokines are all members of the larger IL-10 family, but have been …
Targeting IL-10 family cytokines for the treatment of human diseases
X Wang, K Wong, W Ouyang… - Cold Spring Harbor …, 2019 - cshperspectives.cshlp.org
Members of the interleukin (IL)-10 family of cytokines play important roles in regulating
immune responses during host defense but also in autoimmune disorders, inflammatory …
immune responses during host defense but also in autoimmune disorders, inflammatory …
Targeting JAK kinase in solid tumors: emerging opportunities and challenges
Various human malignancies are characterized by excessive activation of the Janus family
of cytoplasmic tyrosine kinases (JAK) and their associated transcription factors STAT3 and …
of cytoplasmic tyrosine kinases (JAK) and their associated transcription factors STAT3 and …
Janus kinase inhibitors: A therapeutic strategy for cancer and autoimmune diseases
A Hosseini, T Gharibi, F Marofi… - Journal of Cellular …, 2020 - Wiley Online Library
Many cytokines are crucial drivers of cancers and autoimmune conditions. These proteins
bind to receptors and signal their responses through Janus kinase (JAK) and signal …
bind to receptors and signal their responses through Janus kinase (JAK) and signal …
Increased frequencies of Th22 cells as well as Th17 cells in the peripheral blood of patients with ankylosing spondylitis and rheumatoid arthritis
L Zhang, Y Li, Y Li, L Qi, X Liu, C Yuan, N Hu, D Ma… - PloS one, 2012 - journals.plos.org
Background T-helper (Th) 22 is involved in the pathogenesis of inflammatory diseases. The
roles of Th22 cells in the pathophysiological of ankylosing spondylitis (AS) and rheumatoid …
roles of Th22 cells in the pathophysiological of ankylosing spondylitis (AS) and rheumatoid …