Macrophages and neutrophils play a decisive role in host responses to intracellular bacteria
including the agent of tuberculosis (TB), M ycobacterium tuberculosis as they represent the …

Lipid droplets (also known as lipid bodies) are lipid-rich, cytoplasmic organelles that play
important roles in cell signaling, lipid metabolism, membrane trafficking, and the production …

Lipid droplets are dynamic intracellular lipid storage organelles that respond to the
physiological state of cells. In addition to controlling cell metabolism, they play a protective …

The progression of tuberculosis from a latent, subclinical infection to active disease that
culminates in the transmission of infectious bacilli is determined locally at the level of the …

Following detection of bacteria, macrophages switch their metabolism from oxidative
respiration through the tricarboxylic acid cycle to high-rate aerobic glycolysis. This …

Tuberculosis (TB) is characterized by a tight interplay between Mycobacterium tuberculosis
and host cells within granulomas. These cellular aggregates restrict bacterial spreading, but …

Mycobacterium tuberculosis (Mtb) is the causative agent of human tuberculosis (TB) which
primarily infects the macrophages. Nearly a quarter of the world's population is infected …

Two billion people are latently infected with Mycobacterium tuberculosis (Mtb). Mtb-infected
macrophages are likely to be sequestered inside the hypoxic environments of the …

Mycobacterium tuberculosis (Mtb) survives in macrophages by evading delivery to the
lysosome and promoting the accumulation of lipid bodies, which serve as a bacterial source …

Despite the development of potentially curative chemotherapy, tuberculosis (TB) continues
to cause increasing worldwide morbidity and is a leading cause of human mortality in the …