Triazines: syntheses and inverse electron-demand Diels–Alder reactions
Triazines are an important class of six-membered aromatic heterocycles possessing three
nitrogen atoms, resulting in three types of regio-isomers: 1, 2, 4-triazines (a-triazines), 1, 2, 3 …
nitrogen atoms, resulting in three types of regio-isomers: 1, 2, 4-triazines (a-triazines), 1, 2, 3 …
Develo** bioorthogonal probes to span a spectrum of reactivities
SS Nguyen, JA Prescher - Nature Reviews Chemistry, 2020 - nature.com
Bioorthogonal chemistries enable researchers to interrogate biomolecules in living systems.
These reactions are highly selective and biocompatible, and can be performed in many …
These reactions are highly selective and biocompatible, and can be performed in many …
Recent advances of iridium (III) metallophosphors for health-related applications
Phosphorescent transition metal complexes have been intensively investigated, since these
luminophores are distinctively different from fluorescent chromophores in terms of the nature …
luminophores are distinctively different from fluorescent chromophores in terms of the nature …
Functionalized triazines and tetrazines: Synthesis and applications
J Mondal, A Sivaramakrishna - Topics in Current Chemistry, 2022 - Springer
The molecules possessing triazine and tetrazine moieties belong to a special class of
heterocyclic compounds. Both triazines and tetrazines are building blocks and have …
heterocyclic compounds. Both triazines and tetrazines are building blocks and have …
Bioorthogonal control of the phosphorescence and singlet oxygen photosensitisation properties of iridium (iii) tetrazine complexes
In this work, we demonstrate bioorthogonal control of the phosphorescence and singlet
oxygen photosensitisation properties of new iridium (III) tetrazine complexes by different …
oxygen photosensitisation properties of new iridium (III) tetrazine complexes by different …
Catching up with tetrazines: coordination of Re (i) to 1, 2, 4-triazine facilitates an inverse electron demand Diels–Alder reaction with strained alkynes to a greater …
Inverse electron demand Diels Alder (IEDDA) reactions of 1, 2, 4-triazines are of interest to
biorthogonal chemistry but suffer from slow kinetics. It is shown here that coordination of Re …
biorthogonal chemistry but suffer from slow kinetics. It is shown here that coordination of Re …
A Dual‐Purpose Non‐Canonical Amino Acid for the Expanded Genetic Code: Combining Metal‐Binding and Click Chemistry
GJ Day, AV Zaytsev, RC Brewster… - Angewandte …, 2024 - Wiley Online Library
A rationally designed dual‐purpose non‐canonical amino acid (Trz) has been synthesised
and successfully incorporated into a protein scaffold by genetic code expansion. Trz …
and successfully incorporated into a protein scaffold by genetic code expansion. Trz …
Bioorthogonal Cycloadditions of C3‐Trifluoromethylated 1, 2, 4‐Triazines with trans‐Cyclooctenes
V Šlachtová, V Motornov, P Beier… - Chemistry–A European …, 2024 - Wiley Online Library
1, 2, 4‐triazines are a valuable class of heterodienes that can be employed in inverse
electron‐demand Diels–Alder reactions. However, their broader application in …
electron‐demand Diels–Alder reactions. However, their broader application in …
Advances in the Synthesis of Bioorthogonal Reagents: s-Tetrazines, 1, 2, 4-Triazines, Cyclooctynes, Heterocycloheptynes, and trans-Cyclooctenes
Aligned with the increasing importance of bioorthogonal chemistry has been an increasing
demand for more potent, affordable, multifunctional, and programmable bioorthogonal …
demand for more potent, affordable, multifunctional, and programmable bioorthogonal …
Click Chemistry: Reaction Rates and Their Suitability for Biomedical Applications
Click chemistry has become a commonly used synthetic method due to the simplicity,
efficiency, and high selectivity of this class of chemical reactions. Since their initial discovery …
efficiency, and high selectivity of this class of chemical reactions. Since their initial discovery …