Predicting preferential DNA vector insertion sites: implications for functional genomics and gene therapy

CS Hackett, AM Geurts, PB Hackett - Genome biology, 2007 - Springer
Viral and transposon vectors have been employed in gene therapy as well as functional
genomics studies. However, the goals of gene therapy and functional genomics are entirely …

[PDF][PDF] Transposable elements and the detection of somaclonal variation in plant tissue culture: a review.

AS Azman, C Mhiri, MA Grandbastien… - Malaysian Applied …, 2014 - core.ac.uk
Plant tissue culture uses the genetic potential, or totipotency, of plants to regenerate and
give rise to a whole plant. Tissue culture-derived plants are expected to have identical …

Genome-wide analysis of mobile genetic element insertion sites

K Rawal, R Ramaswamy - Nucleic acids research, 2011 - academic.oup.com
Mobile genetic elements (MGEs) account for a significant fraction of eukaryotic genomes
and are implicated in altered gene expression and disease. We present an efficient …

Characterization of the restriction enzyme‐like endonuclease encoded by the Entamoeba histolytica non‐long terminal repeat retrotransposon EhLINE1

VP Yadav, PK Mandal, DN Rao… - The FEBS …, 2009 - Wiley Online Library
The genome of the human pathogen Entamoeba histolytica, a primitive protist, contains non‐
long terminal repeat retrotransposable elements called EhLINEs. These encode reverse …

Differential distribution of a SINE element in the Entamoeba histolytica and Entamoeba dispar genomes: Role of the LINE-encoded endonuclease

V Kumari, R Sharma, VP Yadav, AK Gupta… - BMC genomics, 2011 - Springer
Abstract Background Entamoeba histolytica and Entamoeba dispar are closely related
protistan parasites but while E. histolytica can be invasive, E. dispar is completely non …

Detecting motifs and patterns at mobile genetic element insertion site

BB Dev, A Malik, K Rawal - Bioinformation, 2012 - pmc.ncbi.nlm.nih.gov
Mobile genetic elements (MGEs) occupy major proportion of eukaryotic genomes and are
present in significant numbers in prokaryote genomes also. Here we report a new method …

RetroPred: A tool for prediction, classification and extraction of non-LTR retrotransposons (LINEs & SINEs) from the genome by integrating PALS, PILER, MEME and …

PK Naik, VK Mittal, S Gupta - Bioinformation, 2008 - pmc.ncbi.nlm.nih.gov
The problem of predicting non-long terminal repeats (LTR) like long interspersed nuclear
elements (LINEs) and short interspersed nuclear elements (SINEs) from the DNA sequence …

DRUG SIDE EFFECT NEIGHBOURS: Python Program Checking The Side Effects Of Drug And Covid Drugs.

P Priya, K Rawal, T Sharma, N Arambam - 2022 - osf.io
The most recent SARS-CoV-2 outbreak has brought to light grave worries about the dangers
of new infectious viruses. with limited time for the progress of new drugs. In the clinical area …

A Novel Artificial Intelligence and Machine learning-based scoring system for evaluating re-purposing potential of Valproic Acid drug in COVID-19.

A Aggarwal, R Sinha, P Preeti, T Sharma, K Rawal - 2022 - osf.io
Background Despite widespread vaccinations and the introduction of many repurposed
medications, the rise of COVID-19 reinfection due to the SARS-CoV Omicron (B. 1.1. 529) …

Distribution of MGEs and their insertion sites in the Macaca mulatta genome

K Rawal, A Priya, A Malik, R Bahl… - Mobile Genetic …, 2012 - Taylor & Francis
Mobile genetic elements (MGEs) are fragments of DNA that can move around within the
genome through retrotransposition. These are responsible for various important events such …