The extracellular matrix (ECM) is increasingly recognized as an important regulator in breast
cancer. ECM in breast cancer development features numerous changes in composition and …

The expression of proteoglycans (PGs), essential macromolecules of the tumor
microenvironment, is markedly altered during malignant transformation and tumor …

In hormone-dependent breast cancer, estrogen receptors are the principal signaling
molecules that regulate several cell functions either by the genomic pathway acting directly …

Embryonic development is an exceptionally dynamic process, requiring a provisional
extracellular matrix that is amenable to rapid remodeling, and proteolytic or non-proteolytic …

Purpose: In carcinomas, invasive tumor growth is accompanied by desmoplastic stroma
reaction and facilitated by epithelial-mesenchymal transition (EMT) of cancer cells. We …

Here we report that miR-93, a miRNA in the miR-106B~ 25 cluster, a paralog of the miR-17–
92 cluster, was significantly upregulated in human breast carcinoma tissues. We stably …

Increased expression of the proteoglycan, versican is strongly associated with poor outcome
for many different cancers. Depending on the cancer type, versican is expressed by either …

Glycosylation is the stepwise procedure of covalent attachment of oligosaccharide chains to
proteins or lipids, and alterations in this process have been associated with malignant …

Abstract The non-coding 3′-untranslated region (UTR) plays an important role in the
regulation of microRNA (miRNA) functions, since it can bind and inactivate multiple miRNAs …

Background: A deeper knowledge of the functional versatility and dynamic nature of the
ECM has improved the understanding of cancer biology. Translational Significance: This …