Adaptive deep brain stimulation: From experimental evidence toward practical implementation

WJ Neumann, R Gilron, S Little… - Movement …, 2023 - Wiley Online Library
Closed‐loop adaptive deep brain stimulation (aDBS) can deliver individualized therapy at
an unprecedented temporal precision for neurological disorders. This has the potential to …

Recent trends in wearable device used to detect freezing of gait and falls in people with Parkinson's disease: A systematic review

T Huang, M Li, J Huang - Frontiers in aging neuroscience, 2023 - frontiersin.org
Background The occurrence of freezing of gait (FOG) is often observed in moderate to last-
stage Parkinson's disease (PD), leading to a high risk of falls. The emergence of the …

Proceedings of the ninth annual deep brain stimulation think tank: advances in cutting edge technologies, artificial intelligence, neuromodulation, neuroethics, pain …

JK Wong, G Deuschl, R Wolke, H Bergman… - Frontiers in Human …, 2022 - frontiersin.org
DBS Think Tank IX was held on August 25–27, 2021 in Orlando FL with US based
participants largely in person and overseas participants joining by video conferencing …

Perspective: evolution of control variables and policies for closed-loop deep brain stimulation for Parkinson's disease using bidirectional deep-brain-computer …

HM Bronte-Stewart, MN Petrucci, JJ O'Day… - Frontiers in Human …, 2020 - frontiersin.org
A deep brain stimulation system capable of closed-loop neuromodulation is a type of
bidirectional deep brain-computer interface (dBCI), in which neural signals are recorded …

Unraveling the complexities of programming neural adaptive deep brain stimulation in Parkinson's disease

KB Wilkins, JA Melbourne, P Akella… - Frontiers in Human …, 2023 - frontiersin.org
Over the past three decades, deep brain stimulation (DBS) for Parkinson's disease (PD) has
been applied in a continuous open loop fashion, unresponsive to changes in a given …

Insights into Parkinson's Disease-Related Freezing of Gait Detection and Prediction Approaches: A Meta Analysis

H Elbatanouny, N Kleanthous, H Dahrouj, S Alusi… - Sensors, 2024 - mdpi.com
Parkinson's Disease (PD) is a complex neurodegenerative disorder characterized by a
spectrum of motor and non-motor symptoms, prominently featuring the freezing of gait …

Hope vs. Hype: Closed loop technology will provide more meaningful improvement vs. directional leads in deep brain stimulation

H Bronte-Stewart, A Merola - Parkinsonism & Related Disorders, 2023 - prd-journal.com
The unmet need in current open-loop deep brain stimulation (DBS) can be appreciated by a
comparison to cardiac pacemakers. Cardiac pacemakers can sense the heart's electrical …

PELP: accounting for missing data in neural time series by Periodic Estimation of Lost Packets

EM Dastin-van Rijn, NR Provenza, GS Vogt… - Frontiers in Human …, 2022 - frontiersin.org
Recent advances in wireless data transmission technology have the potential to
revolutionize clinical neuroscience. Today sensing-capable electrical stimulators, known as …

Ramp rate evaluation and configuration for safe and tolerable closed-loop deep brain stimulation

MN Petrucci, KB Wilkins, GC Orthlieb… - 2021 10th …, 2021 - ieeexplore.ieee.org
Closed-loop deep brain stimulation is a novel form of therapy that has shown benefit in
preliminary studies and may be clinically available in the near future. Initial closed-loop …

Quantifying neuro-motor correlations during awake deep brain stimulation surgery using markerless tracking

A Tekriwal, S Baker, E Christensen… - Scientific Reports, 2022 - nature.com
The expanding application of deep brain stimulation (DBS) therapy both drives and is
informed by our growing understanding of disease pathophysiology and innovations in …