Modern advanced therapies for inflammatory bowel diseases: practical considerations and positioning

DI Fudman, RA McConnell, C Ha, S Singh - Clinical Gastroenterology and …, 2024 - Elsevier
The therapeutic armamentarium for management of inflammatory bowel diseases has
expanded dramatically in the last 5 years, with the introduction of several medications with …

Emerging therapies for ulcerative colitis: updates from recent clinical trials

T AlAmeel, A AlMutairdi… - Clinical and Experimental …, 2023 - Taylor & Francis
Ulcerative colitis (UC) is a chronic and progressive inflammatory disorder that affects the
colon. The advent of advanced therapies such as biologic agents and small molecules has …

Inflammation-driven colorectal cancer associated with colitis: from pathogenesis to changing therapy

OM Nardone, I Zammarchi, G Santacroce, S Ghosh… - Cancers, 2023 - mdpi.com
Simple Summary Patients with inflammatory bowel disease (IBD) are at an increased risk of
develo** colorectal cancer (CRC), mainly because of chronic intestinal inflammation …

Immunity in digestive diseases: new drugs for inflammatory bowel disease treatment—insights from Phase II and III trials

S Massironi, F Furfaro, S Bencardino, M Allocca… - Journal of …, 2024 - Springer
Background Inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and
ulcerative colitis (UC), continues to challenge treatment paradigms. Advancements in …

[HTML][HTML] Integrating evidence to guide use of biologics and small molecules for inflammatory bowel diseases

PS Dulai, S Singh, V Jairath, E Wong, N Narula - Gastroenterology, 2024 - Elsevier
Advances in science have led to the development of multiple biologics and small molecules
for the treatment of inflammatory bowel diseases (IBDs). This growth in advanced medical …

Adverse events with risankizumab in the real world: postmarketing pharmacovigilance assessment of the FDA adverse event reporting system

Y Shu, J Chen, Y Ding, Q Zhang - Frontiers in Immunology, 2023 - frontiersin.org
Background Risankizumab, a humanized IgG1 monoclonal antibody that selectively inhibits
IL-23, is currently approved for the treatment of moderate-to-severe plaque psoriasis and …

Risankizumab effectiveness and safety in Crohn's disease: real-world data from a large tertiary center

A Zinger, D Choi, N Choi, RD Cohen… - Clinical …, 2024 - cghjournal.org
IL23 is a recognized cytokine involved in the path-ogenesis of inflammatory bowel disease
(IBD). 1 The first IL23-targeting agent that became available for clinical use in IBD was …

The future of advanced therapies for pediatric Crohn's disease

J Gallagher, JR Rosh, B Sahn - Pediatric Drugs, 2023 - Springer
Pediatric Crohn's disease commonly presents with moderate-to-severe intestinal
inflammation with a greater risk of complications if remission is not achieved. Anti-tumor …

Advancing therapeutic frontiers: a pipeline of novel drugs for luminal and perianal Crohn's disease management

L Bertin, M Crepaldi, M Zanconato… - Therapeutic …, 2024 - journals.sagepub.com
Crohn's disease (CD) is a chronic, complex inflammatory disorder of the gastrointestinal tract
that presents significant therapeutic challenges. Despite the availability of a wide range of …

Positioning risankizumab in the treatment algorithm of moderate-to-severe Crohn's disease

F Lusetti, F D'Amico, M Allocca, F Furfaro, A Zilli… - …, 2024 - Taylor & Francis
Risankizumab is a humanized monoclonal antibody that inhibits the p19 subunit of IL-23
cytokine. Recently it has been approved for the treatment of patients with moderate-to …