Protein shapeshifting in necroptotic cell death signaling
H Hoblos, W Cawthorne, AL Samson… - Trends in Biochemical …, 2024 - cell.com
Necroptosis is a mode of programmed cell death executed by the mixed lineage kinase
domain-like (MLKL) pseudokinase following its activation by the upstream receptor …
domain-like (MLKL) pseudokinase following its activation by the upstream receptor …
Inhibitors identify an auxiliary role for mTOR signalling in necroptosis execution downstream of MLKL activation
Necroptosis is a lytic and pro-inflammatory form of programmed cell death executed by the
terminal effector, the MLKL (mixed lineage kinase domain-like) pseudokinase. Downstream …
terminal effector, the MLKL (mixed lineage kinase domain-like) pseudokinase. Downstream …
Divergent roles of RIPK3 and MLKL in high-fat diet–induced obesity and MAFLD in mice
H Tye, SA Conos, TM Djajawi… - Life Science …, 2025 - life-science-alliance.org
Cell death frequently occurs in the pathogenesis of obesity and metabolic dysfunction–
associated fatty liver disease (MAFLD). However, the exact contribution of core cell death …
associated fatty liver disease (MAFLD). However, the exact contribution of core cell death …
MLKL deficiency elevates testosterone production in male mice independently of necroptotic functions
S Chiou, W Cawthorne, T Soerianto, V Hofferek… - Cell Death & …, 2024 - nature.com
Mixed lineage kinase domain-like (MLKL) is a pseudokinase, best known for its role as the
terminal effector of the necroptotic cell death pathway. MLKL-mediated necroptosis has long …
terminal effector of the necroptotic cell death pathway. MLKL-mediated necroptosis has long …
Seeing is believing: a breakthrough to visualize necrosomes in the tissue
C Yang, JM Blander - EMBO Molecular Medicine, 2024 - embopress.org
Detection of necroptosis in the tissue has been a long-standing roadblock in determining the
disease states and pathological conditions associated with this inflammatory form of cell …
disease states and pathological conditions associated with this inflammatory form of cell …
Inhibition of RIPK1 or RIPK3 kinase activity post ischemia-reperfusion reduces the development of chronic kidney injury
A Pefanis, AK Bongoni, JL McRae… - Biochemical …, 2025 - portlandpress.com
Ischemia-reperfusion injury (IRI) occurs when the blood supply to an organ is temporarily
reduced and then restored. Kidney IRI is a form of acute kidney injury (AKI), which often …
reduced and then restored. Kidney IRI is a form of acute kidney injury (AKI), which often …
RIPK1: Inflamed if you do, inflamed if you don't
NW Hubbard, A Oberst - Immunity, 2024 - Elsevier
RIPK1: Inflamed if you do, inflamed if you don’t - ScienceDirect Skip to main contentSkip to
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article Elsevier logo Journals & Books Help Search My account Sign in View PDF Download …
A necroptotic-to-apoptotic signaling axis underlies inflammatory bowel disease
Inflammatory bowel disease (IBD) is a chronic condition caused by altered cytokine
signaling, maladaptive immunity, dysbiosis, and intestinal barrier dysfunction. Patients with …
signaling, maladaptive immunity, dysbiosis, and intestinal barrier dysfunction. Patients with …
Defining the necroptotic transcriptional signaling pathway
SB Kofman - 2024 - search.proquest.com
Neurons are post-mitotic, non-regenerative cells that have evolved fine-tuned
immunological responses to maintain life-long cellular integrity; this includes resistance to …
immunological responses to maintain life-long cellular integrity; this includes resistance to …
Clinical Relevance of Necroptosis in Ischemia-Reperfusion Injury in Human Lung Transplantation
K Main - 2024 - search.proquest.com
Lung transplantation (LT) is the only treatment for patients suffering from end-stage lung
disease. However, ischemia-reperfusion injury (IRI) limits LTx by predisposing donor lungs …
disease. However, ischemia-reperfusion injury (IRI) limits LTx by predisposing donor lungs …