High mobility group box 1 (HMGB1) is a nonhistone nuclear protein that has multiple
functions according to its subcellular location. In the nucleus, HMGB1 is a DNA chaperone …

Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease …

Significance: A common link between all forms of acute and chronic kidney injuries,
regardless of species, is enhanced generation of reactive oxygen species (ROS) and …

Complex genetic and physiological variations as well as environmental factors that drive
emergence of chromosomal instability, development of unscheduled cell death, skewed …

The complexity of human DNA has been affected by aerobic metabolism, including
endurance exercise and oxygen toxicity. Aerobic endurance exercise could play an …

HMGB1 is a non-histone nuclear protein that can serve as an alarmin to drive the
pathogenesis of inflammatory and autoimmune disease. Although primarily located in the …

Reactive oxygen species (ROS) are generated in skeletal muscle both during the rest and
contractile activity. Myogenic cells are equipped with antioxidant enzymes, like superoxide …

Endometriosis, a common cause of pelvic pain and female infertility, depends on the growth
of vascularized endometrial tissue at ectopic sites. Endometrial fragments reach the …

Skeletal muscle shows high plasticity in response to external demand. Moreover, adult
skeletal muscle is capable of complete regeneration after injury, due to the properties of …

The skeletal muscle is an immunologically unique tissue. Leukocytes, virtually absent in
physiological conditions, are quickly recruited into the tissue upon injury and persist during …