Megakaryocyte-derived platelets and endothelial cells store their hemostatic cargo in α-and
δ-granules and Weibel-Palade bodies, respectively. These storage granules belong to the …

Platelets are small anucleate blood cells supporting vascular function. They circulate in a
quiescent state monitoring the vasculature for injuries. Platelets adhere to injury sites and …

Dysregulation of protein prenylation has been implicated in many diseases, including
Alzheimer's disease (AD). Prenylomic analysis, the combination of metabolic incorporation …

Background: Gastric cancer (GC), one of the most common cancers worldwide, is highly
malignant and fatal. Ras-related protein in brain 31 (RAB31), a member of the RAB family of …

Background Germline mutations in RUNX1 can cause a familial platelet disorder that may
lead to acute myeloid leukemia, an autosomal dominant disorder characterized by moderate …

Patients with familial platelet disorder with a predisposition to myeloid malignancy (FPDMM)
harbor germline monoallelic mutations in a key hematopoietic transcription factor, RUNX-1 …

Platelet α-granules have numerous proteins, some synthesized by megakaryocytes (MK)
and others not synthesized but incorporated by endocytosis, an incompletely understood …

Background Hematopoietic transcription factor RUNX1 is expressed from proximal P2 and
distal P1 promoters to yield isoforms RUNX1 B and C, respectively. The roles of these …

Transcription factor RUNX1 is a master regulator of hematopoiesis and megakaryopoiesis.
RUNX1 haplodeficiency (RHD) is associated with thrombocytopenia and platelet granule …

Pre-implantation mouse blastocyst-derived stem cells, namely embryonic stem cells (ESCs),
trophoblast stem cells (TSCs), and extraembryonic endoderm (XEN) cells, have their own …