Bone tissue engineering using human cells: a comprehensive review on recent trends, current prospects, and recommendations

S Kargozar, M Mozafari, S Hamzehlou, P Brouki Milan… - Applied Sciences, 2019 - mdpi.com
The use of proper cells for bone tissue engineering remains a major challenge worldwide.
Cells play a pivotal role in the repair and regeneration of the bone tissue in vitro and in vivo …

Systematic review on the application of 3D-bioprinting technology in orthoregeneration: current achievements and open challenges

RL Pan, K Martyniak, M Karimzadeh… - Journal of Experimental …, 2022 - Springer
Background Joint degeneration and large or complex bone defects are a significant source
of morbidity and diminished quality of life worldwide. There is an unmet need for a functional …

A phenotypic comparison of osteoblast cell lines versus human primary osteoblasts for biomaterials testing

EM Czekanska, MJ Stoddart, JR Ralphs… - … research Part A, 2014 - Wiley Online Library
Immortalized cell lines are used more frequently in basic and applied biology research than
primary bone‐derived cells because of their ease of access and repeatability of results in …

Zn0. 8Li0. 1Sr—a biodegradable metal with high mechanical strength comparable to pure Ti for the treatment of osteoporotic bone fractures: in vitro and in vivo studies

Z Zhang, B Jia, H Yang, Y Han, Q Wu, K Dai, Y Zheng - Biomaterials, 2021 - Elsevier
The first in vivo investigation of Zn-based biodegradable metal aiming to treat osteoporotic
bone fractures, a soaring threat to human health, is reported in this paper. Among the newly …

Endothelial cells support osteogenesis in an in vitro vascularized bone model developed by 3D bioprinting

I Chiesa, C De Maria, A Lapomarda, GM Fortunato… - …, 2020 - iopscience.iop.org
Bone is a highly vascularized tissue, in which vascularization and mineralization are
concurrent processes during skeletal development. Indeed, both components should be …

Enhancement of critical-sized bone defect regeneration using UiO-66 nanomaterial in rabbit femurs

AA Sadek, M Abd-Elkareem, HN Abdelhamid… - BMC Veterinary …, 2022 - Springer
Background Repair of large-sized bone defects is a challengeable obstacle in orthopedics
and evoked the demand for the development of biomaterials that could induce bone repair …

Dynamic regulation of histone modifications and long-range chromosomal interactions during postmitotic transcriptional reactivation

H Kang, MN Shokhirev, Z Xu, S Chandran… - Genes & …, 2020 - genesdev.cshlp.org
During mitosis, transcription of genomic DNA is dramatically reduced, before it is reactivated
during nuclear reformation in anaphase/telophase. Many aspects of the underlying …

Repair of critical-sized bone defects in rabbit femurs using graphitic carbon nitride (gC3N4) and graphene oxide (GO) nanomaterials

AA Sadek, M Abd-Elkareem, HN Abdelhamid… - Scientific Reports, 2023 - nature.com
Various biomaterials have been evaluated to enhance bone formation in critical-sized bone
defects; however, the ideal scaffold is still missing. The objective of this study was to …

Osteogenic differentiation of human mesenchymal stem cells on substituted calcium phosphate/chitosan composite scaffold

A Ressler, M Antunović, L Teruel-Biosca, GG Ferrer… - Carbohydrate …, 2022 - Elsevier
Ionic substitutions are a promising strategy to enhance the biological performance of
calcium phosphates (CaP) and composite materials for bone tissue engineering …

The osteogenic differentiation of SSEA-4 sub-population of human adipose derived stem cells using silicate nanoplatelets

SM Mihaila, AK Gaharwar, RL Reis, A Khademhosseini… - Biomaterials, 2014 - Elsevier
How to surpass in vitro stem cell differentiation, reducing cell manipulation, and lead the in
situ regeneration process after transplantation, remains to be unraveled in bone tissue …