Early clinical observations and recent systematic studies overwhelmingly document a
greater role for psychosocial stressors in association with the first episode of major affective …

Carcinogenesis may result from the action of any one or a combination of chemical,
physical, biologic, and/or genetic insults to cells. The process of carcinogenesis may be …

The identification of predefined mutations expected to be present in a minor fraction of a cell
population is important for a variety of basic research and clinical applications. Here, we …

HUMAN hepatocellular carcinomas (HCC) from patients in Qidong, an area of high
incidence in China, in which both hepatitis B virus and aflatoxin B1 are risk factors1, were …

Melatonin, the chief secretory product of the pineal gland, is a direct free radical scavenger,
an indirect antioxidant, as well as an important immunomodulatory agent. In both in vitro and …

Digital PCR represents an example of the power of PCR and provides unprecedented
opportunities for molecular genetic analysis in cancer. The technique is to amplify a single …

Many human skin tumors contain mutated p53 genes that probably result from UV exposure.
To investigate the link between UV exposure and p53 gene mutation, we developed two …

There is compelling evidence that cancer arises via a multistep process. For instance, the
exponential relationship of cancer incidence to age suggests that multiple events are …

UV radiation is a potent DNA damaging agent and a known inducer of skin cancer in
experimental animals. There is excellent scientific evidence to indicate that most non …

Cancer epidemiology has identified several metal compounds as human carcinogens.
Recent evidence suggests that carcinogenic metals induce genotoxicity in a multiplicity of …