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Aptamer nanomedicine for cancer therapeutics: barriers and potential for translation
Aptamer nanomedicine, including therapeutic aptamers and aptamer nanocomplexes, is
beginning to fulfill its potential in both clinical trials and preclinical studies. Especially in …
beginning to fulfill its potential in both clinical trials and preclinical studies. Especially in …
Nanoparticle targeting of anti-cancer drugs that alter intracellular signaling or influence the tumor microenvironment
Nanoparticle-based therapeutics are poised to become a leading delivery strategy for
cancer treatment because they potentially offer higher selectivity, reduced toxicity, longer …
cancer treatment because they potentially offer higher selectivity, reduced toxicity, longer …
Ultrasound-triggered disruption and self-healing of reversibly cross-linked hydrogels for drug delivery and enhanced chemotherapy
N Huebsch, CJ Kearney, X Zhao, J Kim… - Proceedings of the …, 2014 - pnas.org
Biological systems are exquisitely sensitive to the location and timing of physiologic cues
and drugs. This spatiotemporal sensitivity presents opportunities for develo** new …
and drugs. This spatiotemporal sensitivity presents opportunities for develo** new …
CTLA-4 blockade synergizes therapeutically with PARP inhibition in BRCA1-deficient ovarian cancer
T Higuchi, DB Flies, NA Marjon… - Cancer immunology …, 2015 - aacrjournals.org
Immune checkpoint blockade has shown significant therapeutic efficacy in melanoma and
other solid tumors, but results in ovarian cancer have been limited. With evidence that tumor …
other solid tumors, but results in ovarian cancer have been limited. With evidence that tumor …
RNA design rules from a massive open laboratory
Self-assembling RNA molecules present compelling substrates for the rational interrogation
and control of living systems. However, imperfect in silico models—even at the secondary …
and control of living systems. However, imperfect in silico models—even at the secondary …
Dual targeted immunotherapy via in vivo delivery of biohybrid RNAi‐peptide nanoparticles to tumor‐associated macrophages and cancer cells
Lung cancer is associated with very poor prognosis and considered one of the leading
causes of death worldwide. Here, highly potent and selective biohybrid RNA interference …
causes of death worldwide. Here, highly potent and selective biohybrid RNA interference …
Functional aspects of PARP1 in DNA repair and transcription
Poly (ADP-ribose) polymerase 1 (PARP1) is an ADP-ribosylating enzyme essential for
initiating various forms of DNA repair. Inhibiting its enzyme activity with small molecules thus …
initiating various forms of DNA repair. Inhibiting its enzyme activity with small molecules thus …
Progress toward in vivo use of siRNAs-II
GR Rettig, MA Behlke - Molecular therapy, 2012 - cell.com
RNA interference (RNAi) has been extensively employed for in vivo research since its use
was first demonstrated in mammalian cells 10 years ago. Design rules have improved, and it …
was first demonstrated in mammalian cells 10 years ago. Design rules have improved, and it …
Advantages and limitations of current techniques for analyzing the biodistribution of nanoparticles
L Arms, DW Smith, J Flynn, W Palmer… - Frontiers in …, 2018 - frontiersin.org
Nanomedicines are typically submicrometer-sized carrier materials (nanoparticles)
encapsulating therapeutic and/or imaging compounds that are used for the prevention …
encapsulating therapeutic and/or imaging compounds that are used for the prevention …
Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression
MS Goldberg, PA Sharp - Journal of Experimental Medicine, 2012 - rupress.org
The development of cancer-specific therapeutics has been limited because most healthy
cells and cancer cells depend on common pathways. Pyruvate kinase (PK) exists in M1 …
cells and cancer cells depend on common pathways. Pyruvate kinase (PK) exists in M1 …