ERYTHROPOIETIN (EPO) is the principal growth factor that promotes the viability,
proliferation, and differentiation of mammalian erythroid progenitor cells, functions that are …

Steel factor (SLF) is a recently identified growth factor which is the gene product of the
murine Steel locus and a ligand for the c-kit tyrosine kinase receptor, the product of the …

Diamond–Blackfan anaemia (DBA) is a constitutional erythroblastopenia characterized by
absent or decreased erythroid precursors. The disease, previously mapped to human …

Mutations of the ribosomal protein S19 (RPS19) gene were recently identified in 10 patients
with Diamond Blackfan anemia (DBA). To determine the prevalence of mutations in this …

This study lays the groundwork for future lentivirus-mediated gene therapy in patients with
Diamond Blackfan anemia (DBA) caused by mutations in ribosomal protein S19 (RPS19) …

BACKGROUND AND OBJECTIVES: Diamond-Blackfan anemia (DBA) is a rare, pure red
blood cell aplasia of childhood caused by an intrinsic defect in erythropoietic progenitors …

Recombinant human erythropoietin (rHuEPO) has revolutionized the treatment of anemia of
chronic renal failure. RHuEPO has been shown to increase survival, decrease …

In vitro hemopoiesis and hemopoietic cytokines production were evaluatedin 9 centenarians
(median age 100.5 years, age range: 100-104 years), 10old people (median age: 71 years …

Programmed cell death, also known as apoptosis, is frequently initiated when cells are
deprived of specific trophic factors. To investigate if accelerated apoptosis contributes to the …

The erythroid defect in Diamond Blackfan anemia (DBA) is known to be intrinsic to the stem
cell, but its molecular pathophysiology remains obscure. Using a 2-phase liquid erythroid …