How cells adopt different identities has long fascinated biologists. Signal transduction in
response to environmental cues results in the activation of transcription factors that …

We analyzed molecular data on 2,579 tumors from The Cancer Genome Atlas (TCGA) of
four gynecological types plus breast. Our aims were to identify shared and unique molecular …

Medulloblastoma (MB) comprises a group of heterogeneous paediatric embryonal
neoplasms of the hindbrain with strong links to early development of the hindbrain 1, 2, 3, 4 …

SCL/TAL1 (stem cell leukemia/T-cell acute lymphoblastic leukemia [T-ALL] 1) is an essential
transcription factor in normal and malignant hematopoiesis. It is required for specification of …

Gene expression in mammals is precisely regulated by the combination of promoters and
gene-distal regulatory regions, known as enhancers. Several studies have suggested that …

Background and Aims DNA damage‐induced NF‐κB activation is a major obstacle to
effective antitumour chemotherapy. Long noncoding RNAs (lncRNAs) that regulate …

The role of ribosome biogenesis in erythroid development is supported by the recognition of
erythroid defects in ribosomopathies in both Diamond-Blackfan anemia and 5q− syndrome …

Polycomb group proteins are important for maintaining gene expression patterns and cell
identity in metazoans. The mammalian Polycomb repressive deubiquitinase (PR-DUB) …

Leukemic blasts are immune cells gone awry. We hypothesized that dysregulation of
inflammatory pathways contributes to the maintenance of their leukemic state and can be …

Conclusions Among NUCs, only ANPs have an additional pharmacological effect
modulating LPS‐mediated cytokine production, which is expected to produce favorable …