As the eye's main load-bearing connective tissue, the sclera is centrally important to vision.
In addition to cooperatively maintaining refractive status with the cornea, the sclera must …

Collagen organization plays an important role in maintaining structural integrity and
determining tissue function. Polarization-sensitive optical coherence tomography (PSOCT) …

Self-assembly of solid organs from single cells would greatly expand applicability of
regenerative medicine. Stem/progenitor cells can self-organize into micro-sized organ units …

With recent advances in cancer therapeutics, there is a great need for improved imaging
methods for characterizing cancer onset and progression in a quantitative and actionable …

Collagen fibers are the main load-bearing component of soft tissues but difficult to
incorporate into models. Whilst simplified homogenization models suffice for some …

Regional variance in human aortic bioarchitecture responsible for the elasticity of the vessel
is poorly understood. The current study quantifies the elements responsible for aortic …

The collagen fibers of the corneoscleral shell play a central role in the eye mechanical
behavior. Although it is well-known that these fibers form a complex three-dimensional …

Current tools lack the temporal or spatial resolution necessary to image many important
aspects of the architecture and dynamics of the optic nerve head (ONH). We evaluated the …

Collagen fibers are a primary load‐bearing component of connective tissues and are
therefore central to tissue biomechanics and pathophysiology. Understanding collagen …

Collagen architecture determines the biomechanical environment in the eye, and thus
characterizing collagen fiber organization and biomechanics is essential to fully understand …