The interplay of fibroblasts, the extracellular matrix, and inflammation in scar formation

L Moretti, J Stalfort, TH Barker, D Abebayehu - Journal of Biological …, 2022 - ASBMB
Various forms of fibrosis, comprising tissue thickening and scarring, are involved in 40% of
deaths across the world. Since the discovery of scarless functional healing in fetuses prior to …

Silk sericin: A versatile material for tissue engineering and drug delivery

L Lamboni, M Gauthier, G Yang, Q Wang - Biotechnology advances, 2015 - Elsevier
Sericin is an inexpensive glycoprotein obtained as a by-product in the silk industry. Its
variable amino acid composition and diverse functional groups confer upon it attractive …

[HTML][HTML] Targeting regenerative exosomes to myocardial infarction using cardiac homing peptide

A Vandergriff, KE Huang, D Shen, S Hu, MT Hensley… - Theranostics, 2018 - ncbi.nlm.nih.gov
Rationale: Cardiac stem cell-derived exosomes have been demonstrated to promote cardiac
regeneration following myocardial infarction in preclinical studies. Recent studies have used …

Exosomes Engineered to Express a Cardiomyocyte Binding Peptide Demonstrate Improved Cardiac Retention in Vivo

KI Mentkowski, JK Lang - Scientific reports, 2019 - nature.com
Injury to the heart results in cardiomyocyte cell death and can lead to pathological
remodeling of remaining cells, contributing to heart failure. Despite the therapeutic potential …

[HTML][HTML] Recent advances in using liposomes for delivery of nucleic acid-based therapeutics

H Nsairat, W Alshaer, F Odeh, E Esawi, D Khater… - OpenNano, 2023 - Elsevier
Nucleic acid therapeutics are rapidly expanding because of recent advancements in
production and purification. This class of therapeutics may change the field of disease …

Nanoparticles for topical drug delivery: Potential for skin cancer treatment

V Krishnan, S Mitragotri - Advanced Drug Delivery Reviews, 2020 - Elsevier
Nanoparticles offer new opportunities for the treatment of skin diseases. The barrier function
of the skin poses a significant challenge for nanoparticles to permeate into the tissue …

Treatment of neurodegenerative disorders through the blood–brain barrier using nanocarriers

N Poovaiah, Z Davoudi, H Peng, B Schlichtmann… - Nanoscale, 2018 - pubs.rsc.org
Neurodegenerative diseases refer to disorders of the central nervous system (CNS) that are
caused by neuronal degradations, dysfunctions, or death. Alzheimer's disease, Parkinson's …

Recent advances in liposome surface modification for oral drug delivery

TX Nguyen, L Huang, M Gauthier, G Yang… - Nanomedicine, 2016 - Taylor & Francis
Oral delivery via the gastrointestinal (GI) tract is the dominant route for drug administration.
Orally delivered liposomal carriers can enhance drug solubility and protect the encapsulated …

Silk fibroin as a natural polymeric based bio-material for tissue engineering and drug delivery systems-A review

SUD Wani, SP Gautam, ZL Qadrie… - International Journal of …, 2020 - Elsevier
The silk fibroin (SF) prepared by Bombyx mori silkworms is one of the mainly abundant
natural fiber and can be obtained simply and economically. SF as bio-material has superior …

Non-genetic engineering of cells for drug delivery and cell-based therapy

Q Wang, H Cheng, H Peng, H Zhou, PY Li… - Advanced drug delivery …, 2015 - Elsevier
Cell-based therapy is a promising modality to address many unmet medical needs. In
addition to genetic engineering, material-based, biochemical, and physical science-based …