The elongation stage of transcription by RNA polymerase II (RNA Pol II) is central to the
regulation of gene expression in response to developmental and environmental cues in …

Abstract FACT (FAcilitates Chromatin Transcription) has long been considered to be a
transcription elongation factor whose ability to destabilize nucleosomes promotes RNAPII …

Cells can be programmed to monitor and react to their environment using genetic circuits.
Design automation software maps a desired circuit function to a DNA sequence, a process …

SPT6 is a histone chaperone that tightly binds RNA polymerase II (RNAPII) during
transcription elongation. However, its primary role in transcription is uncertain. We used …

Genomic DNA is framed by additional layers of information, referred to as the epigenome.
Epigenomic marks such as DNA methylation, histone modifications, and histone variants are …

Transcription elongation requires elaborate coordination between the transcriptional
machinery and chromatin regulatory factors to successfully produce RNA while preserving …

Numerous synthetic biology endeavors require well-tuned co-expression of functional
components for success. Classically, monodirectional promoters (MDPs) have been used for …

Eukaryotic transcription occurs on chromatin, where RNA polymerase II encounters
nucleosomes during elongation. These nucleosomes must unravel for the DNA to enter the …

Spt6 is a conserved factor that controls transcription and chromatin structure across the
genome. Although Spt6 is viewed as an elongation factor, spt6 mutations in Saccharomyces …

Rosmarinic acid is a hydroxycinnamic acid ester commonly found in the Boraginaceae and
Lamiaceae plant families. It exhibits various biological activities, including antioxidant, anti …