Structure-activity relationship (SAR) study and design strategies of nitrogen-containing heterocyclic moieties for their anticancer activities
The present review article offers a detailed account of the design strategies employed for the
synthesis of nitrogen-containing anticancer agents. The results of different studies describe …
synthesis of nitrogen-containing anticancer agents. The results of different studies describe …
Biological activity of oxadiazole and thiadiazole derivatives
UA Atmaram, SM Roopan - Applied Microbiology and Biotechnology, 2022 - Springer
The 5-membered oxadiazole and thiadiazole scaffolds are the most privileged and well-
known heterocycles, being a common and essential feature of a variety of natural products …
known heterocycles, being a common and essential feature of a variety of natural products …
Heterocyclic scaffolds: centrality in anticancer drug development
Cancer has been cursed for human beings for long time. Millions people lost their lives due
to cancer. Despite of the several anticancer drugs available, cancer cannot be cured; …
to cancer. Despite of the several anticancer drugs available, cancer cannot be cured; …
Design, synthesis and ADMET prediction of bis-benzimidazole as anticancer agent
M Rashid - Bioorganic chemistry, 2020 - Elsevier
A new series of bis-benzimidazole clubbed with primary amine (3i-iii) and aromatic
aldehydes (4i-ix) were design and synthesize with an intention to search an anticancer lead …
aldehydes (4i-ix) were design and synthesize with an intention to search an anticancer lead …
Evaluation of oxindole derivatives as a potential anticancer agent against breast carcinoma cells: In vitro, in silico, and molecular docking study
In this study we have performed the in vitro anticancer activity of spiro oxindole derivatives
against MCF-7 (human Adreno carcinoma) and MDA-MB-231 (triple negative breast cancer) …
against MCF-7 (human Adreno carcinoma) and MDA-MB-231 (triple negative breast cancer) …
Benzimidazole clubbed with triazolo-thiadiazoles and triazolo-thiadiazines: New anticancer agents
Two series of Benzimidazole clubbed with triazolo-thiadiazoles (5a–q, 5r, 5s and 5x–a1)
and triazolo-thiadiazines (5t–w) were synthesized with an aim to produce promising …
and triazolo-thiadiazines (5t–w) were synthesized with an aim to produce promising …
Design, synthesis, docking and QSAR study of substituted benzimidazole linked oxadiazole as cytotoxic agents, EGFR and erbB2 receptor inhibitors
The synthesis of benzimidazole linked oxadiazole derivatives designed as potential EGFR
and erbB2 receptor inhibitors with anticancer and apoptotic activity were studied …
and erbB2 receptor inhibitors with anticancer and apoptotic activity were studied …
A comprehensive review of N-heterocycles as cytotoxic agents
Scientific community is striving to understand the role of heterocycles and fused
heterocycles in drug discovery programme due to its impact on multi-drug resistance (MDR) …
heterocycles in drug discovery programme due to its impact on multi-drug resistance (MDR) …
Design and synthesis of a new series of 3, 5-disubstituted-1, 2, 4-oxadiazoles as potential colchicine binding site inhibitors: antiproliferative activity, molecular docking …
RT Diab, ZK Abdel-Sami, EH Abdel-Aal… - New Journal of …, 2021 - pubs.rsc.org
The development of anticancer compounds targeting the colchicine-binding site of tubulin,
termed colchicine-binding site inhibitors (CBSIs) is a promising research area for …
termed colchicine-binding site inhibitors (CBSIs) is a promising research area for …
Synthesis and biological activities of oxadiazole derivatives: a review
A Vaidya, S Jain, P Jain, P Jain, N Tiwari… - Mini Reviews in …, 2016 - ingentaconnect.com
Recently, there has been wide interest in compounds containing the oxadiazole scaffold
because of their unique chemical structure and their broad spectrum of biological properties …
because of their unique chemical structure and their broad spectrum of biological properties …