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[HTML][HTML] Amyloid beta in aging and Alzheimer's disease
Alzheimer's disease (AD), is a progressive neurodegenerative disease that affects behavior,
thinking, learning, and memory in elderly individuals. AD occurs in two forms, early onset …
thinking, learning, and memory in elderly individuals. AD occurs in two forms, early onset …
Inflammation context in Alzheimer's disease, a relationship intricate to define
C Novoa, P Salazar, P Cisternas, C Gherardelli… - Biological research, 2022 - Springer
Abstract Alzheimer's disease (AD), the most common form of dementia, is characterized by
the accumulation of amyloid β (Aβ) and hyperphosphorylated tau protein aggregates …
the accumulation of amyloid β (Aβ) and hyperphosphorylated tau protein aggregates …
Innate immune activation in neurodegenerative diseases
Activation of the innate immune system following pattern recognition receptor binding has
emerged as one of the major pathogenic mechanisms in neurodegenerative disease …
emerged as one of the major pathogenic mechanisms in neurodegenerative disease …
The amyloid cascade hypothesis in Alzheimer's disease: it's time to change our mind
R Ricciarelli, E Fedele - Current neuropharmacology, 2017 - ingentaconnect.com
Since its discovery in 1984, the beta amyloid peptide has treaded the boards of
neurosciences as the star molecule in Alzheimer's disease pathogenesis. In the last decade …
neurosciences as the star molecule in Alzheimer's disease pathogenesis. In the last decade …
The need for new approaches in CNS drug discovery: Why drugs have failed, and what can be done to improve outcomes
VK Gribkoff, LK Kaczmarek - Neuropharmacology, 2017 - Elsevier
An important goal of biomedical research is to translate basic research findings into useful
medical advances. In the field of neuropharmacology this requires understanding disease …
medical advances. In the field of neuropharmacology this requires understanding disease …
Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease
Amyloid-β and tau are the two hallmark proteins in Alzheimer's disease. Although both
amyloid-β and tau have been extensively studied individually with regard to their separate …
amyloid-β and tau have been extensively studied individually with regard to their separate …
[HTML][HTML] Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease
Neural network dysfunction may play an important role in Alzheimer's disease (AD).
Neuronal circuits vulnerable to AD are also affected in human amyloid precursor protein …
Neuronal circuits vulnerable to AD are also affected in human amyloid precursor protein …
Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease
M Kilgore, CA Miller, DM Fass, KM Hennig… - …, 2010 - nature.com
Alzheimer's disease (AD) is a neurodegenerative disorder characterized clinically by
cognitive impairments that progress to dementia and death. The earliest symptoms of AD …
cognitive impairments that progress to dementia and death. The earliest symptoms of AD …
Amyloid β-induced neuronal hyperexcitability triggers progressive epilepsy
R Minkeviciene, S Rheims, MB Dobszay… - Journal of …, 2009 - jneurosci.org
Alzheimer's disease is associated with an increased risk of unprovoked seizures. However,
the underlying mechanisms of seizure induction remain elusive. Here, we performed video …
the underlying mechanisms of seizure induction remain elusive. Here, we performed video …
Amyloid-β and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice
V Rhein, X Song, A Wiesner, LM Ittner… - Proceedings of the …, 2009 - pnas.org
Alzheimer's disease (AD) is characterized by amyloid-beta (Aβ)-containing plaques,
neurofibrillary tangles, and neuron and synapse loss. Tangle formation has been …
neurofibrillary tangles, and neuron and synapse loss. Tangle formation has been …