[HTML][HTML] Amyloid beta in aging and Alzheimer's disease

U Sehar, P Rawat, AP Reddy, J Kopel… - International journal of …, 2022 - mdpi.com
Alzheimer's disease (AD), is a progressive neurodegenerative disease that affects behavior,
thinking, learning, and memory in elderly individuals. AD occurs in two forms, early onset …

Inflammation context in Alzheimer's disease, a relationship intricate to define

C Novoa, P Salazar, P Cisternas, C Gherardelli… - Biological research, 2022 - Springer
Abstract Alzheimer's disease (AD), the most common form of dementia, is characterized by
the accumulation of amyloid β (Aβ) and hyperphosphorylated tau protein aggregates …

Innate immune activation in neurodegenerative diseases

S Castro-Gomez, MT Heneka - Immunity, 2024 - cell.com
Activation of the innate immune system following pattern recognition receptor binding has
emerged as one of the major pathogenic mechanisms in neurodegenerative disease …

The amyloid cascade hypothesis in Alzheimer's disease: it's time to change our mind

R Ricciarelli, E Fedele - Current neuropharmacology, 2017 - ingentaconnect.com
Since its discovery in 1984, the beta amyloid peptide has treaded the boards of
neurosciences as the star molecule in Alzheimer's disease pathogenesis. In the last decade …

The need for new approaches in CNS drug discovery: Why drugs have failed, and what can be done to improve outcomes

VK Gribkoff, LK Kaczmarek - Neuropharmacology, 2017 - Elsevier
An important goal of biomedical research is to translate basic research findings into useful
medical advances. In the field of neuropharmacology this requires understanding disease …

Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease

LM Ittner, J Götz - Nature Reviews Neuroscience, 2011 - nature.com
Amyloid-β and tau are the two hallmark proteins in Alzheimer's disease. Although both
amyloid-β and tau have been extensively studied individually with regard to their separate …

[HTML][HTML] Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease

JJ Palop, J Chin, ED Roberson, J Wang, MT Thwin… - Neuron, 2007 - cell.com
Neural network dysfunction may play an important role in Alzheimer's disease (AD).
Neuronal circuits vulnerable to AD are also affected in human amyloid precursor protein …

Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease

M Kilgore, CA Miller, DM Fass, KM Hennig… - …, 2010 - nature.com
Alzheimer's disease (AD) is a neurodegenerative disorder characterized clinically by
cognitive impairments that progress to dementia and death. The earliest symptoms of AD …

Amyloid β-induced neuronal hyperexcitability triggers progressive epilepsy

R Minkeviciene, S Rheims, MB Dobszay… - Journal of …, 2009 - jneurosci.org
Alzheimer's disease is associated with an increased risk of unprovoked seizures. However,
the underlying mechanisms of seizure induction remain elusive. Here, we performed video …

Amyloid-β and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice

V Rhein, X Song, A Wiesner, LM Ittner… - Proceedings of the …, 2009 - pnas.org
Alzheimer's disease (AD) is characterized by amyloid-beta (Aβ)-containing plaques,
neurofibrillary tangles, and neuron and synapse loss. Tangle formation has been …