Normal circulatory function is a key determinant of disease-free life expectancy (healthspan).
Indeed, pathologies affecting the cardiovascular system, which are growing in prevalence …

Clinicians can encounter sex and gender disparities in diagnostic and therapeutic
responses. These disparities are noted in epidemiology, pathophysiology, clinical …

Abstract Background Emerging evidence from China suggests that coronavirus disease
2019 (COVID-19) is deadlier for infected men than women with a 2.8% fatality rate being …

Heart failure (HF) is marked by distinctive changes in myocardial uptake and utilization of
energy substrates. Among the different types of HF, HF with preserved ejection fraction …

Heart failure (HF) phenotypes differ according to sex. HF preserved ejection fraction (EF)
has a greater prevalence in women and HF reduced EF (HFrEF) in men. Women with HF …

In an aging society, unveiling new anti-aging strategies to prevent and combat aging-related
diseases is of utmost importance. Mitochondria are the primary ATP production sites and key …

Aging is one of the major non-reversible risk factors for several chronic diseases, including
cancer, type 2 diabetes, dementia, and cardiovascular diseases (CVD), and it is a key cause …

Cardiovascular disease is the number one killer of females in the United States today, and
myocardial infarction (MI) plays a role in many of these deaths. Females also present with …

Cardiomyopathies are a heterogeneous collection of diseases that have in common primary
functional and structural abnormalities of the heart muscle, often genetically determined. The …

Nearly all cardiovascular diseases show sexual dimorphisms in prevalence, presentation,
and outcomes. Until recently, most clinical trials were carried out in males, and many animal …