The orbitofrontal cortex and amygdala are involved in emotion and in motivation, but the
relationship between these functions performed by these brain structures is not clear. To …

Evidence is provided for a new conceptualization of the connectivity and functions of the
cingulate cortex in emotion, action, and memory. The anterior cingulate cortex receives …

It is becoming clearer how neurobiological mechanisms generate 'liking'and
'wanting'components of food reward. Mesocorticolimbic mechanisms that enhance …

The inadequacy of a categorial approach to mental health diagnosis is now well-recognised,
with many authors, diagnostic manuals and funding bodies advocating a dimensional, trans …

In this review, we summarize findings supporting the existence of multiple behavioral
strategies for controlling reward-related behavior, including a dichotomy between the goal …

The orbitofrontal cortex represents the reward or affective value of primary reinforcers
including taste, touch, texture, and face expression. It learns to associate other stimuli with …

Understanding how the brain computes value is a basic question in neuroscience. Although
individual studies have driven this progress, meta-analyses provide an opportunity to test …

Interoception, the sense of internal bodily signals, is essential for physiological homeostasis,
cognition, and emotions. While human insular cortex (InsCtx) is implicated in interoception …

Recent behavioral studies in both humans and rodents have found evidence that
performance in decision-making tasks depends on two different learning processes; one …

We describe evidence for dissociable roles of the medial and lateral orbitofrontal cortex
(OFC) in major depressive disorder (MDD) from structure, functional activation, functional …