Macrophages in immunoregulation and therapeutics

S Chen, AFUH Saeed, Q Liu, Q Jiang, H Xu… - Signal transduction and …, 2023 - nature.com
Macrophages exist in various tissues, several body cavities, and around mucosal surfaces
and are a vital part of the innate immune system for host defense against many pathogens …

Macrophage immunometabolism in inflammatory bowel diseases: from pathogenesis to therapy

X Pan, Q Zhu, LL Pan, J Sun - Pharmacology & therapeutics, 2022 - Elsevier
Inflammatory bowel disease (IBD), comprised of ulcerative colitis and Crohn's disease, is a
chronic relapsing inflammatory disease of the gastrointestinal tract that closely related to …

Plant-derived extracellular vesicles as oral drug delivery carriers

Z Fang, K Liu - Journal of Controlled Release, 2022 - Elsevier
Oral administration is one of the most convenient and widely utilized methods of drug
administration. However, many drugs were difficult to be administered orally due to their …

Advancements in hydrogel-based drug delivery systems for the treatment of inflammatory bowel disease: a review

Y Liu, J Huang, S Li, Z Li, C Chen, G Qu, K Chen… - Biomaterials …, 2024 - pubs.rsc.org
Inflammatory bowel disease (IBD) is a chronic disorder that affects millions of individuals
worldwide. However, current drug therapies for IBD are plagued by significant side effects …

Macrophage–endothelial cell crosstalk orchestrates neutrophil recruitment in inflamed mucosa

X Ren, LD Manzanares, EB Piccolo… - The Journal of clinical …, 2023 - jci.org
Neutrophil (PMN) mobilization to sites of insult is critical for host defense and requires
transendothelial migration (TEM). TEM involves several well-studied sequential adhesive …

Mechanistic insights into the role of probiotics in modulating immune cells in ulcerative colitis

N Guo, L Lv - Immunity, inflammation and disease, 2023 - Wiley Online Library
Background Ulcerative colitis (UC) is a persistent inflammatory disorder that affects the
gastrointestinal tract, mainly the colon, which is defined by inflammatory responses and the …

Immune regulation and inflammation inhibition of Arctium lappa L. polysaccharides by TLR4/NF-κB signaling pathway in cells

F Zeng, Y Li, X Zhang, L Shen, X Zhao, T Beta… - International Journal of …, 2024 - Elsevier
Arctium lappa L. polysaccharides (ALP) are important active ingredients of burdocks with
various bioactivities. In the present study, a crude polysaccharide was extracted from A …

A potential therapeutic approach for ulcerative colitis: targeted regulation of macrophage polarization through phytochemicals

K Wang, T Mao, X Lu, M Wang, Y Yun, Z Jia… - Frontiers in …, 2023 - frontiersin.org
Ulcerative colitis (UC), a type of inflammatory bowel disease characterized by recurring and
incurable symptoms, causes immense suffering and economic burden for patients due to the …

[HTML][HTML] Anti-inflammatory effects of Allium cepa L. peel extracts via inhibition of JAK-STAT pathway in LPS-stimulated RAW264. 7 cells

HS Lee, YJ Kwon, EB Seo, SK Kim, H Lee… - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance Allium cepa L.(A. cepa) is one of the oldest cultivated
plants in the world. A. cepa has been used in traditional folk medicine to treat inflammatory …

Extracellular vesicles: the next generation theranostic nanomedicine for inflammatory bowel disease

D Li, M Yang, J Xu, H Xu, M Zhu… - International journal …, 2022 - pmc.ncbi.nlm.nih.gov
The recent rapid development in the field of extracellular vesicles (EVs) based
nanotechnology has provided unprecedented opportunities for nanomedicine platforms. As …