The curious case of the HepG2 cell line: 40 years of expertise
VA Arzumanian, OI Kiseleva… - International journal of …, 2021 - mdpi.com
Liver cancer is the third leading cause of cancer death worldwide. Representing such a
dramatic impact on our lives, liver cancer is a significant public health concern. Sustainable …
dramatic impact on our lives, liver cancer is a significant public health concern. Sustainable …
Transcytosis: crossing cellular barriers
PL Tuma, AL Hubbard - Physiological reviews, 2003 - journals.physiology.org
Tuma, Pamela L., and Ann L. Hubbard. Transcytosis: Crossing Cellular Barriers. Physiol Rev
83: 871–932, 2003; 10.1152/physrev. 00001.2003.—Transcytosis, the vesicular transport of …
83: 871–932, 2003; 10.1152/physrev. 00001.2003.—Transcytosis, the vesicular transport of …
A pathology atlas of the human cancer transcriptome
INTRODUCTION Cancer is a leading cause of death worldwide, and there is great need to
define the molecular mechanisms driving the development and progression of individual …
define the molecular mechanisms driving the development and progression of individual …
Culture and functional characterization of human hepatoma HepG2 cells
MT Donato, L Tolosa, MJ Gómez-Lechón - Protocols in in vitro hepatocyte …, 2015 - Springer
Hepatoma cell lines are frequently used as in vitro alternatives to primary human
hepatocytes. Cell lines are characterized by their unlimited life span, stable phenotype, high …
hepatocytes. Cell lines are characterized by their unlimited life span, stable phenotype, high …
Efficient selection for high-expression transfectants with a novel eukaryotic vector
N Hitoshi, Y Ken-ichi, M Jun-ichi - Gene, 1991 - Elsevier
We have developed a new expression vector which allows efficient selection for
transfectants that express foreign genes at high levels. The vector is composed of a …
transfectants that express foreign genes at high levels. The vector is composed of a …
Impairment of angiogenesis by fatty acid synthase inhibition involves mTOR malonylation
The role of fatty acid synthesis in endothelial cells (ECs) remains incompletely
characterized. We report that fatty acid synthase knockdown (FASN KD) in ECs impedes …
characterized. We report that fatty acid synthase knockdown (FASN KD) in ECs impedes …
Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen
BB Knowles, CC Howe, DP Aden - Science, 1980 - science.org
Analysis of the cell culture fluid from two new human hepatoma-derived cell lines reveals
that 17 of the major human plasma proteins are synthesized and secreted by these cells …
that 17 of the major human plasma proteins are synthesized and secreted by these cells …
Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa
HEPATOCELLULAR carcinoma (HCC) is a prevalent cancer in sub-Saharan Africa and
eastern Asia1. Hepatitis B virus and aflatoxins are risk factors for HCC2, but the molecular …
eastern Asia1. Hepatitis B virus and aflatoxins are risk factors for HCC2, but the molecular …
[HTML][HTML] Hepatitis B virus molecular biology and pathogenesis
As obligate intracellular parasites, viruses need a host cell to provide a milieu favorable to
viral replication. Consequently, viruses often adopt mechanisms to subvert host cellular …
viral replication. Consequently, viruses often adopt mechanisms to subvert host cellular …
p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs
M Müller, S Wilder, D Bannasch, D Israeli… - The Journal of …, 1998 - rupress.org
Chemotherapeutic drugs cause DNA damage and kill cancer cells mainly by apoptosis. p53
mediates apoptosis after DNA damage. To explore the pathway of p53-dependent cell …
mediates apoptosis after DNA damage. To explore the pathway of p53-dependent cell …