Introduction: Precision medicine is the concept of treating diseases based on environmental
factors, lifestyles, and molecular profiles of patients. This approach has been found to …

In-depth modeling of the complex interplay among multiple omics data measured from
cancer cell lines or patient tumors is providing new opportunities toward identification of …

Abstract The International Myeloma Working Group consensus updates the definition for
high-risk (HR) multiple myeloma based on cytogenetics Several cytogenetic abnormalities …

International initiatives such as the Molecular Taxonomy of Breast Cancer International
Consortium are collecting multiple data sets at different genome-scales with the aim to …

The computational prediction of drug responses based on the analysis of multiple types of
genome-wide molecular data is vital for accomplishing the promise of precision medicine in …

Pharmaceutical industry and the art and science of drug development are sorely in need of
novel transformative technologies in the current age of digital health and artificial …

Our knowledge of myeloma genetics remained limited and lagged behind many other
hematologic malignancies because of the inherent difficulties in generating metaphases …

For an increasing number of preclinical samples, both detailed molecular profiles and their
responses to various drugs are becoming available. Efforts to understand, and predict, drug …

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous, immature myeloid cell
population with the ability to suppress innate and adaptive immune responses that promote …

Despite the increasing number of treatment options available for multiple myeloma, relapse
is still inevitable and there remains a critical unmet need for treatments for patients with late …