Breathing matters

CA Del Negro, GD Funk, JL Feldman - Nature Reviews Neuroscience, 2018 - nature.com
Breathing is a well-described, vital and surprisingly complex behaviour, with behavioural
and physiological outputs that are easy to directly measure. Key neural elements for …

Brainstem respiratory networks: building blocks and microcircuits

JC Smith, APL Abdala, A Borgmann, IA Rybak… - Trends in …, 2013 - cell.com
Breathing movements in mammals are driven by rhythmic neural activity generated within
spatially and functionally organized brainstem neural circuits comprising the respiratory …

Understanding the rhythm of breathing: so near, yet so far

JL Feldman, CA Del Negro… - Annual review of …, 2013 - annualreviews.org
Breathing is an essential behavior that presents a unique opportunity to understand how the
nervous system functions normally, how it balances inherent robustness with a highly …

Skn-1a/Pou2f3 functions as a master regulator to generate Trpm5-expressing chemosensory cells in mice

J Yamashita, M Ohmoto, T Yamaguchi, I Matsumoto… - PloS one, 2017 - journals.plos.org
Transient receptor potential channel M5 (Trpm5)-expressing cells, such as sweet, umami,
and bitter taste cells in the oropharyngeal epithelium, solitary chemosensory cells in the …

Flufenamic acid as an ion channel modulator

R Guinamard, C Simard, C Del Negro - Pharmacology & therapeutics, 2013 - Elsevier
Flufenamic acid has been known since the 1960s to have anti-inflammatory properties
attributable to the reduction of prostaglandin synthesis. Thirty years later, flufenamic acid …

9‐phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels

T Grand, M Demion, C Norez, Y Mettey… - British journal of …, 2008 - Wiley Online Library
Background and purpose: TRPM4 and TRPM5 are calcium‐activated non‐selective cation
channels with almost identical characteristics. TRPM4 is detected in several tissues …

Defining the rhythmogenic elements of mammalian breathing

JM Ramirez, N Baertsch - Physiology, 2018 - journals.physiology.org
Breathing's remarkable ability to adapt to changes in metabolic, environmental, and
behavioral demands stems from a complex integration of its rhythm-generating network …

TRPs in the brain

R Vennekens, A Menigoz, B Nilius - Reviews of Physiology, Biochemistry …, 2012 - Springer
The Transient receptor potential (TRP) family of cation channels is a large protein family,
which is mainly structurally uniform. Proteins consist typically of six transmembrane domains …

Transient receptor potential channels meet phosphoinositides

B Nilius, G Owsianik, T Voets - The EMBO journal, 2008 - embopress.org
Transient receptor potential (TRP) cation channels are unique cellular sensors that are
involved in multiple cellular functions, ranging from transduction of sensory signals to the …

State-dependent interactions between excitatory neuromodulators in the neuronal control of breathing

A Doi, JM Ramirez - Journal of Neuroscience, 2010 - jneurosci.org
All neuronal networks are modulated by multiple neuropeptides and biogenic amines. Yet,
few studies investigate how different modulators interact to regulate network activity. Here …