Since the early days of foundational studies of nucleic acids, many chemical moieties have
been discovered to decorate RNA and DNA in diverse organisms. In mammalian cells, one …

The genetic information of human cells is stored in the context of chromatin, which is
subjected to DNA methylation and various histone modifications. Such a 'language'of …

Chemically modified biomacromolecules─ ie, proteins, nucleic acids, glycans, and lipids─
have become crucial tools in chemical biology. They are extensively used not only to …

Contrary to the long-held view that most humans harbour only identical mitochondrial
genomes, deep resequencing has uncovered unanticipated extreme genetic variation within …

Abstract N 6-methyl-2′-deoxyadenosine (6mA or m6dA) has been reported in the DNA of
prokaryotes and eukaryotes ranging from unicellular protozoa and algae to multicellular …

Over 17 and 160 types of chemical modifications have been identified in DNA and RNA,
respectively. The interest in understanding the various biological functions of DNA and RNA …

The discovery of N6-methyldeoxyadenine (6mA) across eukaryotes led to a search for
additional epigenetic mechanisms. However, some studies have highlighted confounding …

RNA modification has recently become a significant process of gene regulation, and the
methyltransferase-like (METTL) family of proteins plays a critical role in RNA modification …

Liver tumour-initiating cells (TICs) contribute to tumour initiation, metastasis, progression
and drug resistance. Metabolic reprogramming is a cancer hallmark and plays vital roles in …

Epigenetic modifications of the nuclear genome, including DNA methylation, histone
modifications and non-coding RNA post-transcriptional regulation, are increasingly being …