The roles of RNA processing in translating genotype to phenotype

KS Manning, TA Cooper - Nature reviews Molecular cell biology, 2017 - nature.com
A goal of human genetics studies is to determine the mechanisms by which genetic variation
produces phenotypic differences that affect human health. Efforts in this respect have …

Intercellular adhesion molecule-1 (ICAM-1): From molecular functions to clinical applications in cancer investigation

WJ Qian, JS Yan, XY Gang, L Xu, S Shi, X Li… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Abstract Intercellular adhesion molecule-1 (ICAM-1) is a versatile molecule that plays a
critical role in various physiological and pathological processes, particularly in tumor …

[HTML][HTML] Tetrandrine suppresses lung cancer growth and induces apoptosis, potentially via the VEGF/HIF-1α/ICAM-1 signaling pathway

Z Chen, L Zhao, F Zhao, G Yang… - Oncology …, 2018 - spandidos-publications.com
The present study investigated the effect of tetrandrine on lung cancer cell growth and
apoptosis, and its possible underlying molecular mechanism. A549 human lung cancer cells …

Contribution of Endothelial Dysfunction to Cancer Susceptibility and Progression: A Comprehensive Narrative Review on the Genetic Risk Component

IG de Melo, V Tavares, D Pereira… - Current Issues in Molecular …, 2024 - mdpi.com
Venous thromboembolism (VTE) is a challenging clinical obstacle in oncological settings,
marked by elevated incidence rates and resulting morbidity and mortality. In the context of …

Grainyhead-like-2 confers NK-sensitivity through interactions with epigenetic modifiers

I MacFawn, H Wilson, LA Selth, I Leighton… - Molecular …, 2019 - Elsevier
Natural Killer (NK) cells suppress tumor initiation and metastasis. Most carcinomas are
heterogeneous mixtures of epithelial, mesenchymal and hybrid tumor cells, but the …

Intercellular adhesion molecule-1 (ICAM-1) polymorphisms and cancer risk: a meta-analysis

D Cheng, B Liang - Iranian journal of public health, 2015 - pmc.ncbi.nlm.nih.gov
Background: Intercellular adhesion molecule-1 (ICAM-1) Lys469Glu (K469E) polymorphism
and Gly 241Arg (G241R) polymorphism might play important roles in cancer development …

Proteomics Identification and Validation of Desmocollin‐1 and Catechol‐O‐Methyltransferase as Proteins Associated with Breast Cancer Cell Migration and …

J Faktor, L Knopfova, P Lapcik, L Janacova… - …, 2019 - Wiley Online Library
Biological treatment of many cancers currently targets membrane bound receptors located
on a cell surface. To identify novel membrane proteins associated with migration and …

Reevaluation of survival and prognostic factors in pathologic stage I lung adenocarcinoma by the new 2009 TNM classification

X Fan, X Zhang, H Wang, B ** - Tumor Biology, 2014 - Springer
The incidence of lung adenocarcinoma has been increased significantly year by year. In this
histologic type, complete surgical resection is commonly chosen as treatment method at the …

Investigation of ICAM-1 and β3 integrin gene variations in patients with brain tumors

U Yilmaz, U Zeybek, OT Kahraman… - Asian Pacific Journal …, 2013 - koreascience.kr
Background: Primary brain tumors constitute a small percent of all malignant cancers, but
their etiology remains poorly understood. ${\beta} 3$ integrin (ITGB3) has been recognized …

KE and EE genotypes of ICAM‐1 gene K469E polymorphism is associated with severe preeclampsia

E Tabatabai, S Salimi… - Disease …, 2014 - Wiley Online Library
Background. Preeclampsia (PE) is one of the most important complications of pregnancy
that is associated with significant mortality and morbidity in mother and fetus. Since the …