Faecal continence is a complex function involving different organs and systems. Faecal
incontinence is a common disorder with different pathogeneses, disabling consequences …

Anal sphincter incontinence is a chronic disease, which dramatically impairs quality of life
and induces high costs for the society. Surgery, considered as the best curative option …

Abstract Matrix metalloproteinase-9 (MMP-9) is a gelatinase, which is a member of the
MMPs family. We know that MMP-9 is not only an important gelatinase to regulate the …

BACKGROUND: Fecal incontinence is a common and debilitating condition, of which the
prevalence increases with age. Several medical and minimally invasive treatment modalities …

Background The efficacy of cell implantation via 3D-spheroids to treat basal tone in fecal
incontinence remains unclear. To address this, in this study, we aimed to identify cell …

Background Fecal incontinence is the uncontrollable loss of stool and has a prevalence of
around 7-15%. This condition has serious implications for patients' quality of life. Current …

AIM To establish a rat model of anal sphincter injury and test different systems to provide
stem cells to injured area. METHODS Adipose-derived stem cells (ASCs) were isolated from …

BACKGROUND: Regenerating muscle at a time remote from injury requires re-expression of
cytokines to attract stem cells to start and sustain the process of repair. OBJECTIVE: We …

Background The artificial anal sphincter is a device used to treat patients with fecal
incontinence who are unable to control their bowel movements on their own. Long‐term …

BACKGROUND: Fecal incontinence is a common disorder, but its pathophysiology is not
completely understood. OBJECTIVE: The aim of this review is to present animal models that …