DNA end resection: mechanism and control
P Cejka, LS Symington - Annual review of genetics, 2021 - annualreviews.org
DNA double-strand breaks (DSBs) are cytotoxic lesions that threaten genome integrity and
cell viability. Typically, cells repair DSBs by either nonhomologous end joining (NHEJ) or …
cell viability. Typically, cells repair DSBs by either nonhomologous end joining (NHEJ) or …
DNA repair pathway choices in CRISPR-Cas9-mediated genome editing
Many clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-
associated protein 9 (Cas9)-based genome editing technologies take advantage of Cas …
associated protein 9 (Cas9)-based genome editing technologies take advantage of Cas …
Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance
D Zatreanu, HMR Robinson, O Alkhatib… - Nature …, 2021 - nature.com
To identify approaches to target DNA repair vulnerabilities in cancer, we discovered
nanomolar potent, selective, low molecular weight (MW), allosteric inhibitors of the …
nanomolar potent, selective, low molecular weight (MW), allosteric inhibitors of the …
The MRE11–RAD50–NBS1 complex conducts the orchestration of damage signaling and outcomes to stress in DNA replication and repair
Genomic instability in disease and its fidelity in health depend on the DNA damage
response (DDR), regulated in part from the complex of meiotic recombination 11 homolog 1 …
response (DDR), regulated in part from the complex of meiotic recombination 11 homolog 1 …
Mechanism and regulation of DNA end resection in eukaryotes
LS Symington - Critical reviews in biochemistry and molecular …, 2016 - Taylor & Francis
The repair of DNA double-strand breaks (DSBs) by homologous recombination (HR) is
initiated by nucleolytic degradation of the 5′-terminated strands in a process termed end …
initiated by nucleolytic degradation of the 5′-terminated strands in a process termed end …
53BP1: a DSB escort
Z Mirman, T de Lange - Genes & development, 2020 - genesdev.cshlp.org
Abstract 53BP1 is an enigmatic DNA damage response factor that gained prominence
because it determines the efficacy of PARP1 inhibitory drugs (PARPi) in BRCA1-deficient …
because it determines the efficacy of PARP1 inhibitory drugs (PARPi) in BRCA1-deficient …
Single-molecule imaging reveals how Mre11-Rad50-Nbs1 initiates DNA break repair
DNA double-strand break (DSB) repair is essential for maintaining our genomes. Mre11-
Rad50-Nbs1 (MRN) and Ku70-Ku80 (Ku) direct distinct DSB repair pathways, but the …
Rad50-Nbs1 (MRN) and Ku70-Ku80 (Ku) direct distinct DSB repair pathways, but the …
Poly (ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks
PARP-1 is rapidly recruited and activated by DNA double-strand breaks (DSBs). Upon
activation, PARP-1 synthesizes a structurally complex polymer composed of ADP-ribose …
activation, PARP-1 synthesizes a structurally complex polymer composed of ADP-ribose …
Replication protein A: a multifunctional protein with roles in DNA replication, repair and beyond
R Dueva, G Iliakis - NAR cancer, 2020 - academic.oup.com
Single-stranded DNA (ssDNA) forms continuously during DNA replication and is an
important intermediate during recombination-mediated repair of damaged DNA. Replication …
important intermediate during recombination-mediated repair of damaged DNA. Replication …
A global view of meiotic double-strand break end resection
EP Mimitou, S Yamada, S Keeney - Science, 2017 - science.org
DNA double-strand breaks that initiate meiotic recombination are exonucleolytically
processed. This 5′→ 3′ resection is a central, conserved feature of recombination but …
processed. This 5′→ 3′ resection is a central, conserved feature of recombination but …