The glucocorticoid receptor in cardiovascular health and disease

B Liu, TN Zhang, JK Knight, JE Goodwin - Cells, 2019 - mdpi.com
The glucocorticoid receptor is a member of the nuclear receptor family that controls many
distinct gene networks, governing various aspects of development, metabolism …

Circular RNA in cardiovascular disease: Expression, mechanisms and clinical prospects

Y Tang, J Bao, J Hu, L Liu, DY Xu - Journal of cellular and …, 2021 - Wiley Online Library
Circular RNAs (circRNAs) are a group of covalently closed, endogenous, non‐coding RNAs,
which exist widely in human tissues including the heart. Increasing evidence has shown that …

Circular RNAs in sepsis: biogenesis, function, and clinical significance

J Beltran-Garcia, R Osca-Verdegal, E Nacher-Sendra… - Cells, 2020 - mdpi.com
Sepsis is a life-threatening condition that occurs when the body responds to an infection that
damages it is own tissues. The major problem in sepsis is rapid, vital status deterioration in …

MicroRNAs and sepsis-induced cardiac dysfunction: a systematic review

AC Manetti, A Maiese, MD Paolo, A De Matteis… - International Journal of …, 2020 - mdpi.com
Sepsis is a severe condition characterized by systemic inflammation. One of the most
involved organs in sepsis is the heart. On the other hand, heart failure and dysfunction are …

Expression of MicroRNAs in sepsis-related organ dysfunction: a systematic review

A Maiese, A Scatena, A Costantino, E Chiti… - International Journal of …, 2022 - mdpi.com
Sepsis is a critical condition characterized by increased levels of pro-inflammatory cytokines
and proliferating cells such as neutrophils and macrophages in response to microbial …

MicroRNAs in inflammatory heart diseases and sepsis-induced cardiac dysfunction: a potential scope for the future?

M Mirna, V Paar, R Rezar, A Topf, M Eber, UC Hoppe… - Cells, 2019 - mdpi.com
Background: MicroRNAs (miRNAs) are small, single-stranded RNA sequences that regulate
gene expression on a post-transcriptional level. In the last few decades, various trials have …

Inhibition of micro RNA miR-122-5p prevents lipopolysaccharide-induced myocardial injury by inhibiting oxidative stress, inflammation and apoptosis via targeting …

W Song, T Zhang, N Yang, T Zhang, R Wen, C Liu - Bioengineered, 2021 - Taylor & Francis
Myocardial injury resulting from sepsis is the leading cause of death worldwide. Micro RNA
miR-122-5p is involved in various physiological and pathological processes and is highly …

Overexpression of miR‐150‐5p alleviates apoptosis in sepsis‐induced myocardial depression

XG Zhu, TN Zhang, R Wen… - BioMed research …, 2020 - Wiley Online Library
Sepsis‐induced myocardial depression has high mortality and is very common in intensive
care units. Previous studies have found that microRNAs play an important role in regulating …

CircTLK1 modulates sepsis‐induced cardiomyocyte apoptosis via enhancing PARP1/HMGB1 axis–mediated mitochondrial DNA damage by sponging miR‐17‐5p

Y Qiu, Y Yu, XM Qin, T Jiang, YF Tan… - Journal of Cellular …, 2021 - Wiley Online Library
Introduction Septic cardiomyopathy is a common complication of sepsis with high morbidity
and mortality, but lacks specific therapy. This study aimed to reveal the role of circTLK1 and …

Identification and validation of ferroptosis-related biomarkers in septic cardiomyopathy via bioinformatics analysis

CW Gong, MM Yuan, BQ Qiu, LJ Wang, HX Zou… - Frontiers in …, 2022 - frontiersin.org
Septic cardiomyopathy (SCM) is a cardiac dysfunction caused by severe sepsis and septic
shock that increases the risk of heart failure and death and its molecular mechanism …