Synthetic glycans to improve current glycoconjugate vaccines and fight antimicrobial resistance

L Del Bino, KE Østerlid, DY Wu, F Nonne… - Chemical …, 2022 - ACS Publications
Antimicrobial resistance (AMR) is emerging as the next potential pandemic. Different
microorganisms, including the bacteria Acinetobacter baumannii, Clostridioides difficile …

Biology of Acinetobacter baumannii: Pathogenesis, Antibiotic Resistance Mechanisms, and Prospective Treatment Options

CR Lee, JH Lee, M Park, KS Park, IK Bae… - Frontiers in cellular …, 2017 - frontiersin.org
Acinetobacter baumannii is undoubtedly one of the most successful pathogens responsible
for hospital-acquired nosocomial infections in the modern healthcare system. Due to the …

[HTML][HTML] Map** Global Prevalence of Acinetobacter baumannii and Recent Vaccine Development to Tackle It

C Ma, S McClean - Vaccines, 2021 - mdpi.com
Acinetobacter baumannii is a leading cause of nosocomial infections that severely threaten
public health. The formidable adaptability and resistance of this opportunistic pathogen have …

The Outer Membrane Proteins OmpA, CarO, and OprD of Acinetobacter baumannii Confer a Two-Pronged Defense in Facilitating Its Success as a Potent Human …

SR Uppalapati, A Sett, R Pathania - Frontiers in microbiology, 2020 - frontiersin.org
Of all the ESKAPE pathogens, carbapenem-resistant and multidrug-resistant Acinetobacter
baumannii is the leading cause of hospital-acquired and ventilator-associated pneumonia …

Deciphering the virulence factors, regulation, and immune response to Acinetobacter baumannii infection

A Shadan, A Pathak, Y Ma, R Pathania… - Frontiers in Cellular and …, 2023 - frontiersin.org
Deciphering the virulence factors, regulation, and immune response to Acinetobacter
baumannii infection Acinetobacter baumannii is a gram-negative multidrug-resistant …

An explorative review on advanced approaches to overcome bacterial resistance by curbing bacterial biofilm formation

F Mohamad, RR Alzahrani, A Alsaadi… - Infection and Drug …, 2023 - Taylor & Francis
The continuous emergence of multidrug-resistant pathogens evoked the development of
innovative approaches targeting virulence factors unique to their pathogenic cascade …

Development of novel nanoantibiotics using an outer membrane vesicle-based drug efflux mechanism

W Huang, Q Zhang, W Li, M Yuan, J Zhou, L Hua… - Journal of controlled …, 2020 - Elsevier
Conventionally used antibiotics are present in low concentrations at the infection site and
require multiple administrations to sustain a continuous bactericidal effect, which not only …

Polydopamine-based nano adjuvant as a promising vaccine carrier induces significant immune responses against Acinetobacter baumannii-associated pneumonia

S Sabzi, M Habibi, F Badmasti, S Shahbazi… - International Journal of …, 2024 - Elsevier
The objective of this study was to assess the effectiveness of polydopamine nanoparticles
(PDANPs) as a delivery system for intranasal antigen administration to prevent …

Designer outer membrane vesicles as immunomodulatory systems–reprogramming bacteria for vaccine delivery

YMD Gnopo, HC Watkins, TC Stevenson… - Advanced Drug Delivery …, 2017 - Elsevier
Vaccines often require adjuvants to be effective. Traditional adjuvants, like alum, activate the
immune response but in an uncontrolled way. Newer adjuvants help to direct the immune …

Genetics, epidemiology, and clinical manifestations of multidrug-resistant Acinetobacter baumannii

P Nasr - Journal of Hospital Infection, 2020 - Elsevier
Acinetobacter baumannii infections have become an emerging health concern in hospitals
across the world and are often associated with nosocomial infections with poorer clinical …