The main theories on the pathogenesis of endometriosis

J Lamceva, R Uljanovs, I Strumfa - International journal of molecular …, 2023 - mdpi.com
Endometriosis is a complex disease, which is defined by abnormal growth of endometrial
tissue outside the uterus. It affects about 10% of women of reproductive age all over the …

The role of gut and genital microbiota and the estrobolome in endometriosis, infertility and chronic pelvic pain

ME Salliss, LV Farland, ND Mahnert… - Human reproduction …, 2022 - academic.oup.com
BACKGROUND Endometriosis is a chronic, burdensome condition that is historically
understudied. Consequently, there is a lack of understanding of the etiology of the disease …

Pharmaceuticals targeting signaling pathways of endometriosis as potential new medical treatment: A review

SW Hung, R Zhang, Z Tan, JPW Chung… - Medicinal research …, 2021 - Wiley Online Library
Endometriosis (EM) is defined as endometrial tissues found outside the uterus. Growth and
development of endometriotic cells in ectopic sites can be promoted via multiple pathways …

Endometriosis-associated macrophages: origin, phenotype, and function

C Hogg, AW Horne, E Greaves - Frontiers in endocrinology, 2020 - frontiersin.org
Endometriosis is a complex, heterogeneous, chronic inflammatory condition impacting~ 176
million women worldwide. It is associated with chronic pelvic pain, infertility, and fatigue, and …

New insights in pathogenesis of endometriosis

PG Signorile, R Viceconte, A Baldi - Frontiers in medicine, 2022 - frontiersin.org
Endometriosis is a gynecological disease characterized by the growth of endometrial glands
and stroma outside the uterine cavity. The incidence of the disease is very high, there are …

Endometriosis: a disease with few direct treatment options

PRC França, ACP Lontra, PD Fernandes - Molecules, 2022 - mdpi.com
Endometriosis is a gynecological condition characterized by the growth of endometrium-like
tissues inside and outside the pelvic cavity. The evolution of the disease can lead to infertility …

Immunological basis of the endometriosis: the complement system as a potential therapeutic target

C Agostinis, A Balduit, A Mangogna, G Zito… - Frontiers in …, 2021 - frontiersin.org
Endometriosis (EM) is a chronic disease characterized by the presence and proliferation of
functional endometrial glands and stroma outside the uterine cavity. Ovaries and pelvic …

Epigenetic dysregulation in endometriosis: implications for pathophysiology and therapeutics

RM Marquardt, DN Tran, BA Lessey… - Endocrine …, 2023 - academic.oup.com
Endometriosis is a prevalent gynecological condition associated with pelvic pain and
infertility. Despite more than a century of research, the etiology of endometriosis still eludes …

Organoid co-culture model of the human endometrium in a fully synthetic extracellular matrix enables the study of epithelial-stromal crosstalk

JS Gnecco, A Brown, K Buttrey, C Ives, BA Goods… - Med, 2023 - cell.com
Background The human endometrium undergoes recurring cycles of growth, differentiation,
and breakdown in response to sex hormones. Dysregulation of epithelial-stromal …

Single-cell insights into epithelial morphogenesis in the neonatal mouse uterus

TE Spencer, MT Lowke… - Proceedings of the …, 2023 - National Acad Sciences
The uterus is vital for successful reproduction in mammals, and two different types of
epithelia (luminal and glandular) are essential for embryo implantation and pregnancy …