Trained immunity: Target for prophylaxis and therapy
Trained immunity is a de facto memory for innate immune responses, leading to long-term
functional reprogramming of innate immune cells. In physiological conditions, trained …
functional reprogramming of innate immune cells. In physiological conditions, trained …
The role of trained immunity in COVID-19: Lessons for the next pandemic
Trained immunity is a long-term increase in responsiveness of innate immune cells, induced
by certain infections and vaccines. During the last 3 years of the COVID-19 pandemic …
by certain infections and vaccines. During the last 3 years of the COVID-19 pandemic …
BCG Vaccination of health care workers does not reduce SARS-CoV-2 infections nor infection severity or duration: a randomized placebo-controlled trial
J Claus, T Ten Doesschate, C Gumbs… - MBio, 2023 - Am Soc Microbiol
ABSTRACT Bacillus Calmette-Guerin (BCG) vaccination has been hypothesized to reduce
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, severity, and/or …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, severity, and/or …
VPM1002 as prophylaxis against severe respiratory tract infections including coronavirus disease 2019 in the elderly: a phase 3 randomized, double-blind, placebo …
AM Blossey, S Brückner, M May… - Clinical Infectious …, 2023 - academic.oup.com
Abstract Background Bacille Calmette-Guérin (BCG) vaccination can potentially reduce the
rate of respiratory infections in vulnerable populations. This study evaluates the safety and …
rate of respiratory infections in vulnerable populations. This study evaluates the safety and …
Intravenous BCG vaccination reduces SARS-CoV-2 severity and promotes extensive reprogramming of lung immune cells
Summary Bacillus Calmette-Guérin (BCG) confers heterologous immune protection against
viral infections and has been proposed as vaccine against SARS-CoV-2 (SCV2). Here, we …
viral infections and has been proposed as vaccine against SARS-CoV-2 (SCV2). Here, we …
Polyfunctional CD4 T-cells correlating with neutralising antibody is a hallmark of COVISHIELDTM and COVAXIN® induced immunity in COVID-19 exposed Indians
S Rakshit, S Babji, C Parthiban, R Madhavan, V Adiga… - npj Vaccines, 2023 - nature.com
Detailed characterisation of immune responses induced by COVID-19 vaccines rolled out in
India: COVISHIELDTM (CS) and COVAXIN®(CO) in a pre-exposed population is only …
India: COVISHIELDTM (CS) and COVAXIN®(CO) in a pre-exposed population is only …
[HTML][HTML] Mannan-Decorated Lipid Calcium Phosphate Nanoparticle Vaccine Increased the Antitumor Immune Response by Modulating the Tumor Microenvironment
L Wu, L Yang, X Qian, W Hu, S Wang… - Journal of Functional …, 2024 - mdpi.com
With the rapid development of tumor immunotherapy, nanoparticle vaccines have attracted
much attention as potential therapeutic strategies. A systematic review and analysis must be …
much attention as potential therapeutic strategies. A systematic review and analysis must be …
[HTML][HTML] The effect of BCG vaccination on infection and antibody levels against SARS-CoV-2—the results of ProBCG: a multicenter randomized clinical trial in Brazil
ABSTRACT Objectives Evatuate if Bacillus Calmette-Guérin (BCG) vaccine could be used
as a tool against SARS-CoV-2 based on the concept of trained immunity. Methods A …
as a tool against SARS-CoV-2 based on the concept of trained immunity. Methods A …
[HTML][HTML] BCG vaccination of healthcare workers for protection against COVID-19: 12-month outcomes from an international randomised controlled trial
Summary Objectives Bacille Calmette-Guérin (BCG) vaccine has immunomodulatory effects
that may provide protection against unrelated infectious diseases. We aimed to determine …
that may provide protection against unrelated infectious diseases. We aimed to determine …
Fiction and facts about BCG imparting trained immunity against COVID-19
The Bacille Calmette-Guérin or BCG vaccine, the only vaccine available against
Mycobacterium tuberculosis can induce a marked Th1 polarization of T-cells, characterized …
Mycobacterium tuberculosis can induce a marked Th1 polarization of T-cells, characterized …