Current advance of nanotechnology in diagnosis and treatment for malignant tumors

B Wang, S Hu, Y Teng, J Chen, H Wang, Y Xu… - … and Targeted Therapy, 2024 - nature.com
Cancer remains a significant risk to human health. Nanomedicine is a new multidisciplinary
field that is garnering a lot of interest and investigation. Nanomedicine shows great potential …

Extracellular vesicles: a rising star for therapeutics and drug delivery

S Du, Y Guan, A **e, Z Yan, S Gao, W Li, L Rao… - Journal of …, 2023 - Springer
Extracellular vesicles (EVs) are nano-sized, natural, cell-derived vesicles that contain the
same nucleic acids, proteins, and lipids as their source cells. Thus, they can serve as natural …

Three 'E'challenges for siRNA drug development

S Guo, M Zhang, Y Huang - Trends in Molecular Medicine, 2024 - cell.com
siRNA therapeutics have gained extensive attention, and to date six siRNAs are approved
for clinical use. Despite being investigated for the treatment of metabolic, cardiovascular …

[HTML][HTML] NK cell-based tumor immunotherapy

H Zhang, L Yang, T Wang, Z Li - Bioactive materials, 2024 - Elsevier
Natural killer (NK) cells display a unique inherent ability to identify and eliminate virus-
infected cells and tumor cells. They are particularly powerful for elimination of hematological …

A Curcumin‐Modified Coordination Polymers with ROS Scavenging and Macrophage Phenotype Regulating Properties for Efficient Ulcerative Colitis Treatment

H Yao, F Wang, H Chong, J Wang, Y Bai… - Advanced …, 2023 - Wiley Online Library
Overexpression of classically activated macrophages (M1) subtypes and assessed reactive
oxygen species (ROS) levels are often observed in patients with ulcerative colitis. At present …

Cold nanozyme for precise enzymatic antitumor immunity

Y Zou, B **, H Li, X Wu, Y Liu, H Zhao, D Zhong… - ACS …, 2022 - ACS Publications
Precise catalysis is pursued for the biomedical applications of artificial enzymes. It is feasible
to precisely control the catalysis of artificial enzymes via tunning the temperature-dependent …

Exosome membrane-coated nanosystems: Exploring biomedical applications in cancer diagnosis and therapy

M Shao, D Lopes, J Lopes, S Yousefiasl… - Matter, 2023 - cell.com
Bio-mimicking principles have recently been proposed for the surface functionalization of
nanoparticles (NPs). Such a strategy is based on camouflaging the NP surface with …

Intracellularly Synthesized Artificial Exosome Treats Acute Lung Injury

L Liang, W Peng, A Qin, J Zhang, R Chen, D Zhou… - ACS …, 2024 - ACS Publications
Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS),
induce high morbidity and mortality rates, which challenge the present approaches for the …

[HTML][HTML] Platelet-derived extracellular vesicles ameliorate intervertebral disc degeneration by alleviating mitochondrial dysfunction

Z Dai, C **a, T Zhao, H Wang, H Tian, O Xu, X Zhu… - Materials Today Bio, 2023 - Elsevier
Mitochondrial dysfunction causes the production of reactive oxygen species (ROS) and
oxidative damage, and oxidative stress and inflammation are considered key factors causing …

CRISPR/Cas9 and chlorophyll coordination micelles for cancer treatment by genome editing and photodynamic therapy

C Zhang, X Wang, G Liu, H Ren, J Liu, Z Jiang… - Small, 2023 - Wiley Online Library
CRISPR/Cas9‐based gene therapy and photodynamic therapy both show promise for
cancer treatment but still have their drawbacks limited by tumor microenvironment and long …