Caloric restriction mimetics against age-associated disease: targets, mechanisms, and therapeutic potential
The increase in life expectancy has boosted the incidence of age-related pathologies
beyond social and economic sustainability. Consequently, there is an urgent need for …
beyond social and economic sustainability. Consequently, there is an urgent need for …
Mitochondrial quality control mechanisms as molecular targets in cardiac ageing
Cardiovascular disease is the leading cause of morbidity and mortality worldwide.
Advancing age is a major risk factor for develo** cardiovascular disease because of the …
Advancing age is a major risk factor for develo** cardiovascular disease because of the …
Targeting autophagy in aging and aging-related cardiovascular diseases
Aging, an irreversible biological process, serves as an independent risk factor for chronic
disease including cancer, pulmonary, neurodegenerative, and cardiovascular diseases. In …
disease including cancer, pulmonary, neurodegenerative, and cardiovascular diseases. In …
The FoxO–autophagy axis in health and disease
Z Cheng - Trends in Endocrinology & Metabolism, 2019 - cell.com
Autophagy controls cellular remodeling and quality control. Dysregulated autophagy has
been implicated in several human diseases including obesity, diabetes, cardiovascular …
been implicated in several human diseases including obesity, diabetes, cardiovascular …
Mitochondrial ROS‐Modulated mtDNA: a potential target for cardiac aging
Y Quan, Y **n, G Tian, J Zhou… - Oxidative medicine and …, 2020 - Wiley Online Library
Mitochondrial DNA (mtDNA) damage is associated with the development of cardiovascular
diseases. Cardiac aging plays a central role in cardiovascular diseases. There is …
diseases. Cardiac aging plays a central role in cardiovascular diseases. There is …
Autophagy in aging-related diseases and cancer: Principles, regulatory mechanisms and therapeutic potential
N Wu, W Zheng, Y Zhou, Y Tian, M Tang, X Feng… - Ageing Research …, 2024 - Elsevier
Macroautophagy/autophagy is primarily accountable for the degradation of damaged
organelles and toxic macromolecules in the cells. Regarding the essential function of …
organelles and toxic macromolecules in the cells. Regarding the essential function of …
Autophagy in cardiovascular aging
Cardiovascular diseases are the most prominent maladies in aging societies. Indeed, aging
promotes the structural and functional declines of both the heart and the blood circulation …
promotes the structural and functional declines of both the heart and the blood circulation …
DNA-PKcs promotes alcohol-related liver disease by activating Drp1-related mitochondrial fission and repressing FUNDC1-required mitophagy
DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a novel housekeeper of
hepatic mitochondrial homeostasis outside the DNA repair process. In this study, DNA-PKcs …
hepatic mitochondrial homeostasis outside the DNA repair process. In this study, DNA-PKcs …
Comparative transcriptomics reveals circadian and pluripotency networks as two pillars of longevity regulation
Mammals differ more than 100-fold in maximum lifespan. Here, we conducted comparative
transcriptomics on 26 species with diverse lifespans. We identified thousands of genes with …
transcriptomics on 26 species with diverse lifespans. We identified thousands of genes with …
Mitophagy inhibitor liensinine suppresses doxorubicin-induced cardiotoxicity through inhibition of Drp1-mediated maladaptive mitochondrial fission
Doxorubicin (DOX) is one of the most effective antineoplastic drugs. However, its clinical
application has been greatly limited due to the development of cardiotoxicity with DOX …
application has been greatly limited due to the development of cardiotoxicity with DOX …