Dopamine: functions, signaling, and association with neurological diseases
The dopaminergic system plays important roles in neuromodulation, such as motor control,
motivation, reward, cognitive function, maternal, and reproductive behaviors. Dopamine is a …
motivation, reward, cognitive function, maternal, and reproductive behaviors. Dopamine is a …
Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease
Involuntary movements, or dyskinesia, represent a debilitating complication of levodopa (L-
dopa) therapy for Parkinson's disease (PD). L-dopa-induced dyskinesia (LID) are ultimately …
dopa) therapy for Parkinson's disease (PD). L-dopa-induced dyskinesia (LID) are ultimately …
[HTML][HTML] Novelty and dopaminergic modulation of memory persistence: a tale of two systems
Adaptation to the ever-changing world is critical for survival, and our brains are particularly
tuned to remember events that differ from previous experiences. Novel experiences induce …
tuned to remember events that differ from previous experiences. Novel experiences induce …
Metabotropic glutamate receptors: from the workbench to the bedside
Metabotropic glutamate (mGlu) receptors were discovered in the mid 1980s and originally
described as glutamate receptors coupled to polyphosphoinositide hydrolysis. Almost 6500 …
described as glutamate receptors coupled to polyphosphoinositide hydrolysis. Almost 6500 …
Cell type-specific plasticity of striatal projection neurons in parkinsonism and L-DOPA-induced dyskinesia
The striatum is widely viewed as the fulcrum of pathophysiology in Parkinson's disease (PD)
and L-DOPA-induced dyskinesia (LID). In these disease states, the balance in activity of …
and L-DOPA-induced dyskinesia (LID). In these disease states, the balance in activity of …
M4 muscarinic receptor signaling ameliorates striatal plasticity deficits in models of L-DOPA-induced dyskinesia
A balanced interaction between dopaminergic and cholinergic signaling in the striatum is
critical to goal-directed behavior. But how this interaction modulates corticostriatal synaptic …
critical to goal-directed behavior. But how this interaction modulates corticostriatal synaptic …
Energy metabolism decline in the aging brain—pathogenesis of neurodegenerative disorders
JW Błaszczyk - Metabolites, 2020 - mdpi.com
There is a growing body of evidencethat indicates that the aging of the brain results from the
decline of energy metabolism. In particular, the neuronal metabolism of glucose declines …
decline of energy metabolism. In particular, the neuronal metabolism of glucose declines …
Presynaptic Mechanisms of l-DOPA-Induced Dyskinesia: The Findings, the Debate, and the Therapeutic Implications
MA Cenci - Frontiers in neurology, 2014 - frontiersin.org
The dopamine (DA) precursor l-DOPA has been the most effective treatment for Parkinson's
disease (PD) for over 40 years. However, the response to this treatment changes with …
disease (PD) for over 40 years. However, the response to this treatment changes with …
Levodopa in the treatment of Parkinson's disease: current status and new developments
D Salat, E Tolosa - Journal of Parkinson's disease, 2013 - content.iospress.com
Levodopa, a dopamine precursor, is an effective and well-tolerated dopamine replacement
agent used to treat Parkinson's disease (PD). Oral levodopa has been widely used for over …
agent used to treat Parkinson's disease (PD). Oral levodopa has been widely used for over …
Catechol-O-Methyltransferase Inhibitors in Parkinson's Disease
T Müller - Drugs, 2015 - Springer
Inhibitors of catechol-O-methyltransferase (COMT) are commonly used as an adjunct to
levodopa in patients with Parkinson's disease (PD) for the amelioration of wearing-off …
levodopa in patients with Parkinson's disease (PD) for the amelioration of wearing-off …