Evaluating Z-FA-FMK, a host cathepsin L protease inhibitor, as a potent and broad-spectrum antiviral therapy against SARS-CoV-2 and related coronaviruses
Abstract Even though the World Health Organization announced the end of the COVID-19
pandemic as a global public health emergency on May 5, 2023, SARS-CoV-2 continues to …
pandemic as a global public health emergency on May 5, 2023, SARS-CoV-2 continues to …
Cathepsin inhibition modulates metabolism and polarization of tumor-associated macrophages
D Oelschlaegel, T Weiss Sadan, S Salpeter, S Krug… - Cancers, 2020 - mdpi.com
Simple Summary Stroma-infiltrating tumor-associated macrophages (TAM) play an important
role in regulating tumor progression and chemoresistance. Many tumor-infiltrating …
role in regulating tumor progression and chemoresistance. Many tumor-infiltrating …
N-Terminomics/TAILS profiling of macrophages after chemical inhibition of legumain
Legumain (asparaginyl endopeptidase) is the only protease with a preference for cleavage
after asparagine residues. Increased legumain activity is a hallmark of inflammation …
after asparagine residues. Increased legumain activity is a hallmark of inflammation …
UPLC-orbitrap-MS-based metabolic profiling of HaCaT cells exposed to withanolides extracted from Datura metel. L: Insights from an untargeted metabolomics
T Li, Z Wei, H Kuang - Journal of Pharmaceutical and Biomedical Analysis, 2021 - Elsevier
In recent decades, more and more attention to the withanolides extracted from Datura metel.
L has been paid due to their anti-psoriatic effects. Withanolides have also been reported to …
L has been paid due to their anti-psoriatic effects. Withanolides have also been reported to …
[PDF][PDF] Lucilia sericata Larval Secretions Stimulating Wound Healing Effects on Rat Dermal Fibroblast Cells.
The extract from larval Lucilia sericata is used clinically to promote wound healing and
tissue regeneration. However, its effect and underlying mechanisms on fibroblast cells …
tissue regeneration. However, its effect and underlying mechanisms on fibroblast cells …
Using proteomics for an insight into the performance of activated sludge in a lab-scale WWTP
A Azizan, F Kaschani, H Barinas, S Blaskowski… - International …, 2020 - Elsevier
The performance of a lab-scale wastewater treatment plant during the start-up phase was
investigated. A period of varying pH resulted in the loss of ammonium removal efficiency …
investigated. A period of varying pH resulted in the loss of ammonium removal efficiency …
Associations of cathepsins with pulmonary arterial hypertension mediated by circulating metabolites: A Mendelian randomization study
S Yang, Q Chen, B Yang - Medicine, 2025 - journals.lww.com
The correlation between cathepsins and pulmonary arterial hypertension (PAH) is well-
established, but the causative link between them remains uncertain. This study aimed to …
established, but the causative link between them remains uncertain. This study aimed to …
Immunostimulant bathing influences the expression of immune-and metabolic-related genes in Atlantic Salmon alevins
F Figueiredo, H Kristoffersen, S Bhat, Z Zhang… - Biology, 2021 - mdpi.com
Simple Summary Activation of immune cells is bioenergetically expensive, requiring precise
control of cellular metabolism. This applies also to innate immune cells. The current study …
control of cellular metabolism. This applies also to innate immune cells. The current study …
Effect of vitrification on the expression of genes in porcine blastocysts derived from in vitro matured oocytes
T Wiesak, E Goryszewska-Szczurek - Systems Biology in …, 2022 - Taylor & Francis
This study aimed to examine the effect of vitrification on the expression of genes that are
crucial for porcine early embryo development; cathepsin B (CTSB), growth differentiation …
crucial for porcine early embryo development; cathepsin B (CTSB), growth differentiation …